Active Recombinant Human PAK1
Cat.No. : | PAK1-17H |
Product Overview : | PAK1KD is a recombinant wild type human PAK1 kinase domain (amino acids 248–545 of full-length human PAK1) expressed in E. coli and purified to near homogeneity. PAK1KD does not have the inhibitory switch domain and has high specific activity. |
- Specification
- Gene Information
- Related Products
Description : | Human PAK1 kinase (UniProt: Q13153; NCBI: NM_002576) belongs to a family of p21-activated kinases. These serine/threonine kinases serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 kinase regulates cell motility and morphology. |
Source : | E. coli |
Species : | Human |
Form : | 1 mg/ml in Storage Buffer of 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT. |
Bio-activity : | 32,638 pmoles/min/μg |
Molecular Mass : | The calculated mass is 33,646. PAK1KD is fully phosphorylated at T423 and partially phosphorylated at additional sites with measured mass of 33,728 (1P), 33,808 (2P), 33,889 (3P), and 33,968 (4P). |
AA Sequence : | GPHPSDEEILEKLRSIVSVGDPKKK YTRFEKIGQGASGTVYTAMDVATGQ EVAIKQMNLQQQPKKELIINEILVM RENKNPNIVNYLDSYLVGDELWVVM EYLAGGSLTDVVTETCMDEGQIAAV CRECLQALEFLHSNQVIHRDIKSD NILLGMDGSVKLTDFGFCAQITPEQ SKRSTMVGTPYWMAPEVVTRKAYGP KVDIWSLGIMAIEMIEGEPPYLNE NPLRALYLIATNGTPELQNPEKLSA IFRDFLNRCLEMDVEKRGSAKELLQ HQFLKIAKPLSSLTPLIAAAKEAT KNNH |
Applications : | Enzymatic studies, inhibitor screen, and selectivity profiling |
Storage : | Stable at -70oC for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -70oC. |
Gene Name : | PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 [ Homo sapiens ] |
Official Symbol : | PAK1 |
Synonyms : | PAK1; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) , p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related); serine/threonine-protein kinase PAK 1; STE20 homolog; yeast; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); PAKalpha; MGC130000; MGC130001; |
Gene ID : | 5058 |
mRNA Refseq : | NM_001128620 |
Protein Refseq : | NP_001122092 |
MIM : | 602590 |
UniProt ID : | Q13153 |
Chromosome Location : | 11q13-q14 |
Pathway : | Activation of Rac, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; |
Function : | ATP binding; collagen binding; nucleotide binding; protein binding; contributes_to protein binding; protein kinase activity; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
PAK1-5512H | Recombinant Human Protein (Cdc42/Rac)-Activated Kinase 1, GST-tagged | +Inquiry |
PAK1-768H | Recombinant Human PAK1 Protein, His-tagged | +Inquiry |
PAK1-3921R | Recombinant Rat PAK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pak1-4662M | Recombinant Mouse Pak1 Protein, Myc/DDK-tagged | +Inquiry |
PAK1-1259H | Active Recombinant Human PAK1, GST-tagged | +Inquiry |
◆ Lysates | ||
PAK1-1275HCL | Recombinant Human PAK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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