Active Recombinant Human PCSK2, His-tagged
Cat.No. : | PCSK2-88H |
Product Overview : | Recombinant Human PCSK2 (Gly110-Asn638) fused with 6His tag at Cterminal, was expressed in CHO Cells. |
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Description : | This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | CHO Cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Gly110 |
Form : | Supplied as a 0.2 µm filtered solution in Tris, NaCl and CaCl2. |
Bio-activity : | Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specific activity is >60 pmol/min/µg, as measured under the described conditions. |
Molecular Mass : | 59 kDa |
Endotoxin : | < 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening. |
Gene Name : | PCSK2 proprotein convertase subtilisin/kexin type 2 [ Homo sapiens (human) ] |
Official Symbol : | PCSK2 |
Synonyms : | PCSK2; PC2; NEC2; SPC2; NEC 2; NEC-2; proprotein convertase subtilisin/kexin type 2; neuroendocrine convertase 2; prohormone convertase 2; KEX2-like endoprotease 2; EC 3.4.21.94 |
Gene ID : | 5126 |
mRNA Refseq : | NM_002594 |
Protein Refseq : | NP_002585 |
MIM : | 162151 |
UniProt ID : | P16519 |
Chromosome Location : | 20p11.2 |
Pathway : | Insulin Processing; Metabolism of proteins; Peptide hormone metabolism |
Function : | protein binding; protein complex binding; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
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PCSK2-2083R | Recombinant Rat PCSK2 Protein (109-637 aa), His-tagged | +Inquiry |
PCSK2-3151R | Recombinant Rhesus Macaque PCSK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
PCSK2-523H | Recombinant Human PCSK2 Protein, His-tagged | +Inquiry |
Pcsk2-4721M | Recombinant Mouse Pcsk2 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
PCSK2-3371HCL | Recombinant Human PCSK2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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