Active Recombinant Human PDE4D protein, GST-tagged
Cat.No. : | PDE4D-10H |
Product Overview : | Recombinant Human PDE4D(2–507 aa) fused with GST tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% Glycerol and 16 mM Glutathione. |
Bio-activity : | ≥ 13,600 pmol/min/µg |
Molecular Mass : | 84 kDa |
Purity : | > 86% |
Unit Definition : | One unit is defined as the amount of enzyme that will convert 1 pmole of 3', 5'-cAMP to 5'-AMP per minute at 37 centigrade. |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | >6 months at -80 centigrade. Avoid freeze/thaw cycles. |
Concentration : | 0.27 mg/ml |
Gene Name : | PDE4D phosphodiesterase 4D, cAMP-specific [ Homo sapiens ] |
Official Symbol : | PDE4D |
Synonyms : | PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3, phosphodiesterase 4D, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3); cAMP-specific 3,5-cyclic phosphodiesterase 4D; phosphodiesterase E3 dunce homolog (Drosophila); cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); DPDE3; PDE43; STRK1; HSPDE4D; PDE4DN2; FLJ97311; DKFZp686M11213; |
Gene ID : | 5144 |
mRNA Refseq : | NM_001197221 |
Protein Refseq : | NP_001184150 |
MIM : | 600129 |
UniProt ID : | Q08499 |
Chromosome Location : | 5q12 |
Pathway : | DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; cAMP binding; drug binding; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
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PDE4D-303H | Recombinant Human PDE4D Protein, His/GST-tagged | +Inquiry |
PDE4D-11D | Active Recombinant Dog PDE4D Protein (2-679), N-GST tagged | +Inquiry |
PDE4D-3992R | Recombinant Rat PDE4D Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PDE4D-3350HCL | Recombinant Human PDE4D 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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