Active Recombinant Human PI4KB protein, GST-tagged
Cat.No. : | PI4KB-162H |
Product Overview : | Recombinant Human PI4KB fused with an N-terminal GST tag was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | PI4KB is a member of the phosphatidylinositol 4-kinase family (PI4K) and is the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP3). PI4KB regulates the golgi disintegration/reorganization during mitosis possibly via the phosphorylation of phosphatidylinositol. PI4KB is a type III enzyme that is sensitive to wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. PI4KB is critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules. PI4KB inhibits the insulin-stimulated translocation of glucose transporter-4 in mouse adipocytes through its interaction with neuronal calcium sensor-1. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 4800 nmol/min/mg |
Molecular Mass : | ~120 kDa |
Purity : | >90% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | PI4KB phosphatidylinositol 4-kinase, catalytic, beta [ Homo sapiens ] |
Official Symbol : | PI4KB |
Synonyms : | PI4KB; phosphatidylinositol 4-kinase, catalytic, beta; PIK4CB; phosphatidylinositol 4-kinase beta; PI4K BETA; pi4K92; PtdIns 4-kinase beta; type III phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, wortmannin-sensitive; NPIK; PI4K92; PI4KBETA; PI4K-BETA; PI4KIIIBETA; FLJ30129; DKFZp686O1820; |
Gene ID : | 5298 |
mRNA Refseq : | NM_001198773 |
Protein Refseq : | NP_001185702 |
MIM : | 602758 |
UniProt ID : | Q9UBF8 |
Chromosome Location : | 1q21 |
Pathway : | 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Inositol phosphate metabolism, PI=> |
Function : | 1-phosphatidylinositol 4-kinase activity; ATP binding; kinase activity; nucleotide binding; |
Products Types
◆ Recombinant Protein | ||
PI4KB-6716M | Recombinant Mouse PI4KB Protein, His (Fc)-Avi-tagged | +Inquiry |
PI4KB-0821H | Recombinant Human PI4KB Protein (G2-M816), His/GST tagged | +Inquiry |
PI4KB-4100R | Recombinant Rat PI4KB Protein, His (Fc)-Avi-tagged | +Inquiry |
PI4KB-0820H | Recombinant Human PI4KB Protein (G2-M816), Tag Free | +Inquiry |
Pi4kb-336M | Recombinant Mouse Pi4kb Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
PI4KB-3206HCL | Recombinant Human PI4KB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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