Active Recombinant Human PTPN1 protein, Bioactivity Validated
Cat.No. : | PTPN1-31256TH |
Product Overview : | Recombinant Human PTPN1(1-321aa) was expressed in E. coli. |
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Description : | The protein coding region of the catalytic domain of PTP-1B (amino acids 1-321) was cloned into an E. coli expression vector. The catalytic domain of PTP-1B was overexpressed in E. coli as a soluble protein, and it was purified by conventional column chromatographic techniques. |
Source : | E. coli |
Species : | Human |
Form : | Liquid. 25 mM Tris-HCl, pH7.5, 2 mM beta-mercaptoethanol, 1 mM EDTA, 1 mMDTT, 20% Glycerol |
Bio-activity : | Specific activity is > 10,000 units/mg, and is defined as the amount of enzyme that hydrolyze 1.0 nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37°C. |
Molecular Mass : | 37.3 kDa (321 aa) |
AA Sequence : | MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YILTQGPLPNTCGHFWEMVW EQKSRGVVML NRVMEKGSLK CAQYWPQKEE KEMIFEDTNL KLTLISEDIK SYYTVRQLEL ENLTTQETRE ILHFHYTTWPDFGVPESPAS FLNFLFKVRE SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL LEMRKFRMGL IQTADQLRFSYLAVIEGAKF IMGDSSVQDQ WKELSHEDLE PPPEHIPPPP RPPKRILEPH N |
Purity : | > 95% by SDS - PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Publication : |
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor (2017)
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Gene Name : | PTPN1 protein tyrosine phosphatase, non-receptor type 1 [ Homo sapiens ] |
Official Symbol : | PTPN1 |
Synonyms : | PTPN1; protein tyrosine phosphatase, non-receptor type 1; PTP1B; tyrosine-protein phosphatase non-receptor type 1; protein tyrosine phosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental; |
Gene ID : | 5770 |
mRNA Refseq : | NM_002827 |
Protein Refseq : | NP_002818 |
MIM : | 176885 |
UniProt ID : | P18031 |
Chromosome Location : | 20q13.1-q13.2 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; EGF receptor (ErbB1) signaling pathway, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Hemostasis, organism-specific biosystem; |
Function : | ephrin receptor binding; hydrolase activity; insulin receptor binding; protein binding; protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; zinc ion binding; |
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◆ Lysates | ||
PTPN1-2686HCL | Recombinant Human PTPN1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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