Active Recombinant Human Thyroid Peroxidase, MIgG2a Fc-tagged
Cat.No. : | TPO-1334H |
Product Overview : | The extracellular domain of human TPO(AAC37566.1)(Ser22-Gly353) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. |
Source : | CHO cell |
Species : | Human |
Tag : | MIgG2a Fc-tagged |
Form : | Lyophilized from 0.2 μm-filtered solution in PBS. |
Bio-activity : | Measured in a cell proliferation assay. |
Molecular Mass : | 62KDa (monomer) |
AA Sequence : | Ser22-Gly353 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100 μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | TPO thyroid peroxidase [ Homo sapiens ] |
Official Symbol : | TPO |
Synonyms : | TPO; thyroid peroxidase; TPX; thyroperoxidase; thyroid microsomal antigen; MSA; TDH2A; |
Gene ID : | 7173 |
mRNA Refseq : | NM_000547 |
Protein Refseq : | NP_000538 |
MIM : | 606765 |
UniProt ID : | P07202 |
Chromosome Location : | 2p25 |
Pathway : | Amine-derived hormones, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; |
Function : | calcium ion binding; heme binding; iodide peroxidase activity; oxidoreductase activity; peroxidase activity; |
Products Types
◆ Recombinant Protein | ||
TPO-68C | Recombinant Chicken TPO Protein | +Inquiry |
TPO-1487H | Recombinant Human TPO Protein, His-tagged | +Inquiry |
TPO-10H | Recombinant Human TPO Protein, Fc-tagged | +Inquiry |
Tpo-202T | Active Recombinant Rat Tpo Protein (174 aa), His-tagged | +Inquiry |
Tpo-201T | Active Recombinant Mouse Tpo Protein | +Inquiry |
◆ Native Protein | ||
TPO-8266H | Native Human Thyroid Peroxidase | +Inquiry |
TPO-702H | Native Human Thyroid Peroxidase | +Inquiry |
◆ Lysates | ||
TPO-442HCL | Recombinant Human TPO cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket