Active Recombinant Human TNFRSF10B
Cat.No. : | TNFRSF10B-518H |
Product Overview : | Recombinant Human TNFRSF10B produced in E. coli is approximately 14.8 kDa, a single non-glycosylated polypeptide chain containing 132 amino acids. |
- Specification
- Gene Information
- Related Products
Description : | Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. 1 The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells. 2 TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 determined by its ability to inhibit TRAIL-mediated cytotoxicity using mouse L929 cells treated with TRAILl is less than 2 ng/ml, corresponding to a specific activity of >5.0 × 10 5 IU/mg. |
Molecular Mass : | 14.8 kDa |
AA Sequence : | ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES |
Endotoxin : | Less than 1EU/μg of rHusTRAIL-R2/TNFRSF10B as determined by LAL method. |
Purity : | >97% by SDS-PAGE and HPLC analyses. |
Usage : | This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
Storage : | This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles. |
Reconstitution : | We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ] |
Official Symbol : | TNFRSF10B |
Synonyms : | TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5; |
Gene ID : | 8795 |
mRNA Refseq : | NM_003842 |
Protein Refseq : | NP_003833 |
MIM : | 603612 |
UniProt ID : | O14763 |
Chromosome Location : | 8p22-p21 |
Pathway : | Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; |
Function : | TRAIL binding; protein binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
TNFRSF10B-2136H | Recombinant Human TNFRSF10B Protein, His-tagged | +Inquiry |
TNFRSF10B-462H | Recombinant Human TNFRSF10B Protein, His-tagged | +Inquiry |
TNFRSF10B-156H | Recombinant Human TNFRSF10B Protein, C-His-tagged | +Inquiry |
TNFRSF10B-1999H | Recombinant Human TNFRSF10B Protein, MYC/DDK-tagged | +Inquiry |
TNFRSF10B-599H | Active Recombinant Human TNFRSF10B Protein, His-Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
TNFRSF10B-2829HCL | Recombinant Human TNFRSF10B cell lysate | +Inquiry |
TNFRSF10B-2397MCL | Recombinant Mouse TNFRSF10B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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