Active Recombinant Human TNFRSF10B Protein

• Cat.No.: TNFRSF10B-15H
• Product Overview: Recombinant Human TNFRSF10B Protein without tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
• Source: HEK293
• Species: Human
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 6 ng/mL, measured in a cell proliferation assay using RPMI-8226 cells in the presence of 25 ng/mL of human TRAIL.
• Molecular Mass: ~15 kDa, observed by reducing SDS-PAGE.
• AA Sequence: ALITQQDLAPQQRAAPQQKRSSPSE GLCPPGHHISEDGRDCISCKYGQDY STHWNDLLFCLRCTRCDSGEVELSP CTTTRNTVCQCEEGTFREEDSPEMC RKCRTGCPRGMVKVGDCTPWSDIEC VHKE
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: >95% by SDS-PAGE and HPLC analyses.
• Storage: Lyophilized recombinant Human TRAIL Receptor-2 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human TRAIL Receptor-2 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: TNFRSF10B TNF receptor superfamily member 10b [ Homo sapiens (human) ]
• Official Symbol: TNFRSF10B
• Synonyms: TNFRSF10B; TNF receptor superfamily member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; TNF-related apoptosis-inducing ligand receptor 2; apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; p53-regulated DNA damage-inducible cell death receptor(killer); tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9
• Gene ID: 8795
• mRNA Refseq: NM_003842
• Protein Refseq: NP_003833
• MIM: 603612
• UniProt ID: Q7Z2I8