Active Recombinant Human TNFRSF4, Fc-tagged
Cat.No. : | TNFRSF4-441H |
Product Overview : | Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully. |
Source : | HEK293 Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Blocks T cell proliferation induced by CD134L. |
Molecular Mass : | ~70kDa (SDS-PAGE) |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 1mg/ml after reconstitution. |
Gene Name : | TNFRSF4 tumor necrosis factor receptor superfamily, member 4 [ Homo sapiens ] |
Official Symbol : | TNFRSF4 |
Synonyms : | TNFRSF4; tumor necrosis factor receptor superfamily, member 4; TXGP1L; tumor necrosis factor receptor superfamily member 4; ACT35; CD134; OX40; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; |
Gene ID : | 7293 |
mRNA Refseq : | NM_003327 |
Protein Refseq : | NP_003318 |
MIM : | 600315 |
UniProt ID : | P43489 |
Chromosome Location : | 1p36 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; |
Function : | binding; receptor activity; tumor necrosis factor-activated receptor activity; |
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TNFRSF4-393H | Active Recombinant Human TNFRSF4 Protein (Met1-Ala216), His-tagged, Biotinylated | +Inquiry |
TNFRSF4-683M | Recombinant Mouse TNFRSF4 Protein, Fc-tagged | +Inquiry |
Tnfrsf4-450R | Recombinant Rat Tnfrsf4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF4-2422HCL | Recombinant Human TNFRSF4 cell lysate | +Inquiry |
TNFRSF4-1762MCL | Recombinant Mouse TNFRSF4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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