Active Recombinant Human VSTM2B protein, Fc-Avi-tag-tagged, Biotinylated
Cat.No. : | VSTM2B-051H |
Product Overview : | Biotinylated Recombinant Human VSTM2B(Ala29-Thr263) protein, fused to Fc-Avi-tag tag at the C-terminus, was expressed in CHO cells . |
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Description : | V-set and transmembrane domain-containing protein 2B (VSTM2B) is a type I transmembrane protein belonging to the immunoglobulin (Ig) superfamily. There have been 8 VSTM family members identified and several have been shown to exhibit immunosuppressive activity (1). Human VSTM2B consists of an extracellular domain (ECD) with an Ig-like V-type domain, a transmembrane domain, and single amino acid (aa) in the cytoplasm. The mature ECD of human VSTM2B shares 86% and 85% aa sequence identity with mouse and rat VSTM2B, respectively. Currently, both the expression pattern and biological functions of VSTM2B remain unknown. Our in-house data show that VSTM2B inhibits the human T cell activation, including anti-CD3 induced IL-2, IFN-gamma secretion, and T cell proliferation. Our Avi-tag Biotinylated Recombinant VSTM2B features biotinylation at a single site contained within the Avi-tag, a unique 15 amino acid peptide. Protein orientation will be uniform when bound to streptavidin-coated surface due to the precise control of biotinylation and the rest of the protein is unchanged so there is no interference in the protein's bioactivity. |
Source : | CHO cells |
Species : | Human |
Tag : | Fc-Avi |
Predicted N Terminal : | Ala29 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | 60-72 kDa, under reducing conditions |
Protein length : | Ala29-Thr263 |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Applications : | Bioactivity |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Gene Name : | V-set and transmembrane domain containing 2B[ Homo sapiens ] |
Official Symbol : | VSTM2B |
Gene ID : | 342865 |
mRNA Refseq : | NM_001146339.1 |
Protein Refseq : | NP_001139811.1 |
UniProt ID : | A6NLU5 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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