Active Recombinant Mouse AF251705, Fc Chimera

• Cat.No.: AF251705-457M
• Product Overview: Recombinant Mouse AF251705 (Accession # BAC80269) was produced in Chinese Hamster Ovary cell line, CHO-derived.

Specification

• Source: CHO cells
• Species: Mouse
• Tag: Fc Chimera
• Predicted N Terminal: Cys22
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with 500 ng/mL anti-CD3 and serially diluted Recombinant Mouse CD300c/LMIR2 Fc Chimera. The ED50 for this effect is typically 0.6-3 µg/mL. Optimal dilutions should be determined by each laboratory for each application.
• Molecular Mass: Recombinant Mouse AF251705, Fc Chimera has a calculated MW of 46 kDa (monomer). In SDS-PAGE migrates as 55-65 kDa, reducing conditions.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: AF251705 cDNA sequence AF251705 [ Mus musculus (house mouse) ]
• Official Symbol: AF251705
• Synonyms: AF251705; cDNA sequence AF251705; CLM4; DIgR1; Igsf7; Lmir2; Cd300c; Cd300d; MAIR-II; CMRF35-like molecule; CLM; Cd300C antigen; Cd300D antigen; MAIR-2; dendritic cell-derived Ig-like receptor 1; dendritic cell-derived immunoglobulin receptor 1; immunoglobulin superfamily member 7; immunoglobulin superfamily, member 7; leukocyte mono-Ig-like receptor 2; myeloid-associated immunoglobulin-like receptor 2; myeloid-associated immunoglobulin-like receptor II
• Gene ID: 140497
• mRNA Refseq: NM_134158
• Protein Refseq: NP_598919
• UniProt ID: Q7TSN2
• Chromosome Location: 11 E2; 11 80.57 cM

Reviews

12/22/2021

Elucidating protein-protein interactions in protein folding and misfolding diseases.

12/27/2018

Deciphering protein-protein interactions in metabolic disorders for therapeutic interventions.

04/21/2017

Exploring protein-protein interactions in cell cycle regulation for understanding cell division.

Q&As

Are there any genetic variations or mutations in the gene associated with AF251705 protein that impact its expression or function, and what are the implications for cellular processes or disease susceptibility?

Genetic variations or mutations in the gene associated with AF251705 protein may impact its expression or function, potentially affecting cellular processes or disease susceptibility.

How does AF251705 protein contribute to disease development or pathophysiological conditions, and what are the underlying molecular mechanisms?

AF251705 protein may contribute to disease development or pathophysiological conditions, and the underlying molecular mechanisms are currently being investigated.

What is the subcellular localization of AF251705 protein, and how can it be experimentally determined?

The subcellular localization of AF251705 protein can be determined experimentally using techniques such as immunofluorescence microscopy or subcellular fractionation.

What experimental techniques or assays have been used to study the functional significance of AF251705 protein?

Various experimental techniques or assays have been used to study the functional significance of AF251705 protein, including functional genomics approaches, protein-protein interaction studies, or cellular assays.

How does dysregulation or dysfunction of AF251705 protein affect cellular homeostasis, molecular signaling networks, or disease progression?

Dysregulation or dysfunction of AF251705 protein can disrupt cellular homeostasis, perturb molecular signaling networks, and contribute to disease progression.

Does AF251705 protein interact with specific molecules or participate in protein complexes, and what are the functional implications of these interactions?

AF251705 protein may interact with specific molecules or participate in protein complexes, influencing various cellular functions and processes.

What is the role of AF251705 protein in cellular processes, and how can its function be investigated experimentally?

The role of AF251705 protein in cellular processes can be investigated experimentally using functional assays or loss-of-function/gain-of-function studies.

Are there any known post-translational modifications or regulatory mechanisms that modulate the activity or stability of AF251705 protein?

Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AF251705 protein.

How is the expression of AF251705 protein regulated, and are there any factors or signaling pathways involved in its expression control?

The expression of AF251705 protein is regulated, and there may be specific factors or signaling pathways involved in its expression control.

Can AF251705 protein be targeted or manipulated to modulate cellular processes or serve as a potential therapeutic target?

AF251705 protein holds the potential to be targeted or manipulated to modulate cellular processes or serve as a potential therapeutic target, warranting further investigation for its therapeutic applications.