Active Recombinant Mouse Carm1 Protein, FLAG-tagged

• Cat.No.: Carm1-23M
• Product Overview: Recombinant Mouse Carm1 fused with FLAG tag at N-terminal was expressed in Insect cells.

Specification

• Description: Carm1 / Prmt4 (Coactivator-associated arginine methyltransferase 1 or Carm1) is a protein arginine N-methyltransferase that catalyzes the mono- and asymmetric dimethylation of arginine residues in its substrate proteins. It serves as a coactivator of transcription and also plays a role in nuclear receptors. Carm1 methylates histone H3 at Arg2, Arg17 and Arg26; it also methylates a number of non-histone substrates involved in the regulation and mechanism of gene expression.
• Source: Insect cells
• Species: Mouse
• Tag: FLAG
• Form: In 25 mM HEPES (pH 7.5), 300 mM NaCl, 5% glycerol and 0.2 mg/ml 3X FLAG peptide.
• Bio-activity: Specifically mediates the methylation of H3R17.
• Molecular Mass: ~67 kDa
• Applications: Recombinant Carm1 / Prmt4 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.6 µg/µl

Gene Information

• Gene Name: Carm1 coactivator-associated arginine methyltransferase 1 [ Mus musculus ]
• Official Symbol: Carm1
• Synonyms: CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; protein arginine methyltransferase; protein arginine N-methyltransferase 4; Prmt4; MGC46828
• Gene ID: 59035
• mRNA Refseq: NM_021531
• Protein Refseq: NP_067506
• UniProt ID: Q9WVG6