Active Recombinant Mouse Defb2 Protein (51 aa)
Cat.No. : | Defb2-036D |
Product Overview : | Recombinant Mouse Defb2 Protein without tag was expressed in E. coli. |
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Description : | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. |
Source : | E. coli |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | Determined Sterile Filtered White lyophilized (freeze-dried) powder.by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/mL. |
Molecular Mass : | Approximately 5.54 kDa, a single non-glycosylated polypeptide chain containing 51 amino acids. |
Protein Length : | 51 |
AA Sequence : | AVGSLKSIGYEAELDHCHTNGGYCV RAICPPSARRPGSCFPEKNPCCKYM K |
Endotoxin : | Less than 1 EU/mg of rMuBD-2 as determined by LAL method. |
Purity : | >98% by SDS-PAGE and HPLC analyses. |
Storage : | This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 to -70 centigrade. Avoid repeated freeze/thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | Defb2 defensin beta 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Defb2 |
Synonyms : | Defb2; defensin beta 2; BD-2; beta-defensin 2 |
Gene ID : | 13215 |
mRNA Refseq : | NM_010030 |
Protein Refseq : | NP_034160 |
UniProt ID : | P82020 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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