Active Recombinant Mouse Pdgfbb Protein (110 aa)
Cat.No. : | Pdgfb-316P |
Product Overview : | Recombinant mouse Platelet-Derived Growth Factor-BB (rmPDGF-BB) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 110 amino acids each. A fully biologically active molecule, rmPDGF-BB has a molecular mass of 24.7 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In vivo PDGF-BB is mainly produced in heart and placenta, and predominantly expressed by osteoblasts, fibroblasts, smooth muscle cells, and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis, development of human skeleton, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. Therefore, PDGF-BB and its related pathways are potential pharmacological targets. |
Source : | E. coli |
Species : | Mouse |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 2.5 ng/mL, measured by a cell proliferation assay using 3T3 Cells, corresponding to a specific activity of > 4 × 10^5 units/mg. |
Molecular Mass : | 24.7 kDa, observed by non-reducing SDS-PAGE. |
Protein Length : | 110 |
AA Sequence : | MSLGSLAAAEPAVIAECKTRTEVFQ ISRNLIDRTNANFLVWPPCVEVQRC SGCCNNRNVQCRASQVQMRPVQVRK IEIVRKKPIFKKATVTLEDHLACKC ETIVTPRPVT |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% by SDS-PAGE analysis. |
Storage : | Lyophilized recombinant mouse Platelet-Derived Growth Factor-BB (rmPDGF-BB) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rmPDGF-BB remains stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against 10 mM Sodium Citrate, pH 3.0. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/mL. |
Gene Name : | Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus ] |
Official Symbol : | Pdgfb |
Synonyms : | PDGFB; platelet derived growth factor, B polypeptide; platelet-derived growth factor subunit B; c-sis; PDGF-2; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; Sis; PDGF-B; |
Gene ID : | 18591 |
mRNA Refseq : | NM_011057 |
Protein Refseq : | NP_035187 |
UniProt ID : | P31240 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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