Active Recombinant Mouse Tgfbr2 Protein (Ile24-Asp184), mFc-tagged
Cat.No. : | Tgfbr2-01M |
Product Overview : | Recombinant Mouse TGF-beta RII (Ile24-Asp184) Protein with Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line. |
- Specification
- Gene Information
- Related Products
Description : | Enables SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; and prostate cancer. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). |
Source : | Mouse myeloma cell line |
Species : | Mouse |
Tag : | C-hFc |
Form : | Disulfide-linked homodimer |
Bio-activity : | Measured by its ability to inhibit TGF-beta 1 activity on HT-2 mouse T cells. The ED50 for this effect is 10-70 ng/mL. |
Molecular Mass : | Predicted Molecular Mass: 44.6 kDa (monomer) SDS-PAGE: 60-65 kDa, reducing conditions |
Protein Length : | Ile24-Asp184 |
N-terminal Sequence Analysis : | Ile24 |
Endotoxin : | <0.10 EU/μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | Tgfbr2 transforming growth factor, beta receptor II [ Mus musculus (house mouse) ] |
Official Symbol : | Tgfbr2 |
Synonyms : | Tgfbr2; transforming growth factor, beta receptor II; DNIIR; RIIDN; TBR-II; TbetaRII; TbetaR-II; 1110020H15Rik; TGF-beta receptor type-2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; transforming growth factor-beta receptor type II; EC 2.7.11.30 |
Gene ID : | 21813 |
mRNA Refseq : | NM_009371 |
Protein Refseq : | NP_033397 |
UniProt ID : | Q62312 |
Products Types
◆ Recombinant Protein | ||
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TGFBR2-453H | Recombinant Human TGFBR2 Protein, Fc-tagged | +Inquiry |
Tgfbr2-8722R | Active Recombinant Rat Tgfbr2 protein(Met1-Gln166), hFc-tagged | +Inquiry |
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◆ Lysates | ||
TGFBR2-1374RCL | Recombinant Rat TGFBR2 cell lysate | +Inquiry |
TGFBR2-1291CCL | Recombinant Cynomolgus TGFBR2 cell lysate | +Inquiry |
TGFBR2-2842HCL | Recombinant Human TGFBR2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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