Active Recombinant Rat Advanced Glycosylation End Product-Specific Receptor, Fc-tagged
Cat.No. : | Ager-540R |
Product Overview : | Recombinant Rat Agerprotein was expressed in Murine myeloma cell line with the Fc part of RatRAGE Gln24-Ala342 (N-terminus) and Human IgG1 Pro100-Lys330 (C-terminus). |
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Cat. No. : | Ager-540R |
Description : | Advancedglycation endproducts (AGEs) are adducts formed by the nonenzymatic glycationof macromolecules. Ager formation is acceleratedin oxidative and hyperglycemic conditions, diabetes, renal failure,atherosclerosis, Alzheimer's disease, arthritis, and in normal aging. Receptorfor advanced glycation endproducts (Ager) isa 35 kDa type I transmembrane protein belonging the immunoglobulinsuperfamily. Besides AGEs, Ager bindsβamyloid peptide, S100/calgranulin family proteins, HMGB1/amphoterin, andleukocyte integrins. Mature rat Agerconsists of a 319 amino acid (aa) extracellular domain (ECD) with one Iglike V-typedomain and two Ig-like Ctype domains, a 21 aa transmembrane segment, and a 40aa cytoplasmic domain. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in PBS. |
N-terminalSequence : | Gln24 predicted |
Molecular Weight : | 60 kDa (monomer) |
Activity : | Measured by itsbinding ability in a functional ELISA. rr Ager/Fc Chimera immobilized at 5μg/mL (100 μL/well) on a goat antihuman IgG Fc antibodycoated plate (0.5μg/well) can bind biotinylated advanced glycation endproducts of bovine serumalbumin with a linear range of 0.02-15 μg/mL. |
Endotoxin Level : | < 1.0EU per 1 μg of the protein by the LAL method. |
SDS-PAGE : | 80-90 kDa,reducing conditions. |
Purity : | > 95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 100μg/mL in sterile PBS. |
Storage : | Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. |
Gene Name : | Ager advanced glycosylation endproduct-specific receptor [ Rattus norvegicus ] |
Official Symbol : | Ager |
Synonyms : | Ager; advancedglycosylation end product-specific receptor; RAGE; receptor foradvanced glycosylation end products; advanced glycosylation end product-specificreceptor variant 2; advanced glycosylation end product-specific receptorvariant 3; advanced glycosylation end product-specific receptor variant 5 |
Gene ID : | 81722 |
mRNA Refseq : | NM_053336 |
Protein Refseq : | NP_445788 |
Chromosome Location : | 20p12 |
Pathway : | Activated TLR4signalling; Immune System; Innate Immune System; MyD88 cascade initiated onplasma membrane; MyD88 dependent cascade initiated on endosome; MyD88-independentcascade initiated on plasma membrane; MyD88:Mal cascade initiated on plasmamembrane; NFkB and MAP kinases activation mediated by TLR4 signalingrepertoire; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; TAK1activates NFkB by phosphorylation and activation of IKKs complex; TRAF6Mediated Induction of proinflammatory cytokines; TRAF6 mediated NF-kBactivation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9activation; Toll Like Receptor 10 (TLR10) Cascade; Toll Receptor Cascades |
Function : | S100 alpha binding;S100 beta binding; advanced glycation end-product receptor activity; proteinbinding; receptor activity |
Products Types
◆ Recombinant Protein | ||
AGER-05H | Recombinant Human AGER Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
Ager-713R | Recombinant Rat Ager Protein, His/GST-tagged | +Inquiry |
AGER-3137H | Active Recombinant Human AGER protein(Met1-Ala344), hFc-tagged | +Inquiry |
AGER-2C | Recombinant Canine AGER Protein, His (Fc)-Avi-tagged | +Inquiry |
Ager-2R | Recombinant Rat Ager Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AGER-2546HCL | Recombinant Human RAGE 293 Cell Lysate | +Inquiry |
AGER-1480HCL | Recombinant Human AGER cell lysate | +Inquiry |
AGER-2215MCL | Recombinant Mouse AGER cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAGER is involved in bone metabolism and might influence osteoporosis and bone diseases.
AGER levels might serve as biomarkers for certain diseases, including diabetes.
AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.
AGER contributes to skin aging through oxidative stress and collagen damage.
AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.
Yes, AGER activation contributes to inflammation and immune responses.
AGER activation can impair wound healing through inflammation and oxidative stress.
AGER contributes to neuroinflammation and might play a role in neurodegeneration.
AGER contributes to diabetic nephropathy and kidney dysfunction.
AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.
AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.
Researchers explore compounds that modulate AGER to mitigate its effects.
AGER contributes to diabetic complications by promoting inflammation and tissue damage.
AGER is studied for its implications in aging, diabetes, and various age-related diseases.
AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).
Consuming a low-AGE diet may help reduce AGER activation and its negative effects.
AGER activation affects immune cell functions and influences immune responses.
AGER activation is linked to cardiovascular diseases, including atherosclerosis.
Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.
Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.
Customer Reviews (5)
Write a reviewIt's quality was evident in consistent results across replicates.
Protein consistently upregulated the expression of tissue-specific markers.
Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.
It’s consistent outcomes supported reliable statistical analysis.
Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.
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