AICAR
Cat.No. : | AICAR-83 |
Product Overview : | An adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate (ZMP), which stimulates AMPK activity. Formula: C9H14N4O5. CAS#: 2627-69-2. |
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Description : | Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. |
Form : | Off-white solid. |
Molecular Mass : | 258.2 |
Purity : | ≥98% (TLC) |
Storage : | -20°C |
Reconstitution : | Soluble in water (9mg/ml). |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionActivation of AMPK by AICAR triggers responses that enhance cellular energy production and utilization, such as increasing glucose uptake and fatty acid oxidation.
AICAR's activation of AMPK can trigger mitochondrial biogenesis, enhancing the cell's capacity for oxidative metabolism and energy production.
AICAR's modulation of AMPK can influence immune responses and inflammation by affecting energy availability and metabolic pathways in immune cells.
Techniques such as liquid chromatography-mass spectrometry (LC-MS) or high-performance liquid chromatography (HPLC) can be employed to quantify AICAR levels in biological samples.
AICAR is produced from inosine monophosphate (IMP) during certain metabolic processes and serves as an intermediate in the biosynthesis of purine nucleotides. It can also activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis.
Chemists can modify AICAR's structure to improve its pharmacokinetics, cellular uptake, or target specificity for potential therapeutic applications.
AICAR can serve as a valuable tool in research to dissect metabolic pathways, investigate energy-related processes, and explore cellular responses to stress and environmental cues.
AICAR's ability to activate AMPK has led to investigations into its potential therapeutic applications for metabolic disorders like diabetes and obesity.
AICAR is formed through the enzymatic conversion of IMP to AICAR by the enzyme AICAR transformylase, which plays a role in purine nucleotide biosynthesis.
AICAR has been studied for its potential to mimic the metabolic effects of exercise, such as enhancing fatty acid oxidation and glucose utilization.
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