AMC [7-Amino-4-methylcoumarin]
Cat.No. : | DYE-154 |
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Description : | 7-Amino-4-methylcoumarin (AMC) is a well-known laboratory reagent employed in the preparation of fluorogenic AMC-based substrates for the detection of proteolytic enzyme activity. AMC has been utilized as a fluorescent probe to analyze glycoproteins" monosaccharides and N-linked oligosaccharides via chromatography and has been used as a laser dye. Recent research shows that AMC was extracted from an endophytic Xylaria fungal species and exhibited strong antibacterial and antifungal activities in vitro against Aspergillus, Candida, Escherichia, Staphylococcus, Salmonella and Vibrio species, among others. This product is also useful as a reference standard in enzymatic assays. |
CAS number : | 26093-31-2 |
Molecular Mass : | 175.18 |
Formula : | C10H9NO2 |
Ex(nm) : | 351 |
Em(nm) : | 430 |
Solvent : | DMSO |
Storage : | Store at -20°C in the dark. Dessicated. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAlterations in AMC expression levels or mutations can impact cellular apoptosis sensitivity and resistance, influencing the susceptibility of cells to apoptotic stimuli.
AMC promotes the permeabilization of the mitochondrial outer membrane, leading to the release of pro-apoptotic factors, such as cytochrome c, into the cytoplasm.
The interaction between AMC and other cellular processes, such as autophagy or cell cycle progression, can influence apoptotic outcomes by crosstalk mechanisms and molecular signaling networks.
AMC interacts with Bcl-2 family proteins, such as Bax and Bak, to regulate mitochondrial outer membrane permeabilization and initiate apoptotic signaling.
Post-translational modifications, including phosphorylation and proteolytic cleavage, regulate the activity and stability of AMC, modulating its involvement in mitochondrial apoptosis.
AMC exhibits a primarily mitochondrial localization, although it may translocate to the cytoplasm and other subcellular compartments under specific conditions.
AMC is a crucial component of the apoptosome, which forms upon cytochrome c release and activates caspase cascades, ultimately leading to apoptosis.
AMC expression and activation are regulated in response to cellular stress or apoptotic stimuli through complex mechanisms involving transcriptional regulation, post-translational modifications, and protein-protein interactions.
AMC plays a role in regulating mitochondrial dynamics by participating in fission-fusion processes and influencing the balance between mitochondrial fusion and fission events.
AMC contributes to mitochondrial quality control mechanisms by participating in mitophagy, the selective clearance of damaged mitochondria, and influencing mitochondrial biogenesis processes.
Customer Reviews (3)
Write a reviewCompatible with multiple protein detection platforms.
Comprehensive analysis of protein-protein interaction networks.
Enhanced assay sensitivity for detection of low-abundance proteins.
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