Human Factor-VIII
Cat.No. : | F8-3065H |
Product Overview : | Human Facor VIII produced from Human Plasma is effective in the correction and prevention of severe bleeding episodes attributed to Factor VIII deficiency. The Factor-VIII is purified by proprietary chromatographic techniques. |
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Cat. No. : | F8-3065H |
Description : | Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. |
Source : | Human Plasma. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation : | The lyophilized protein 200IU/ml was lyophilized from a sterile solution containing 1.5% Glycine, 160mM Calcium chloride and 25mM NaCitrate and 25mM NaCl. |
Solubility : | It is recommended to reconstitute the lyophilized Factor-VIII in sterile 18MΩ-cm H2O at a concentration of 200IU/ml, which can then be further diluted to other aqueous solutions. Make sure that the vial has reached room temperature prior to its reconstitution, otherwise it might precipitate. |
Stability : | Lyophilized Factor-VIII although stable at room temperature for 1 week, should be stored desiccated between 2-8°C. Upon reconstitution Factor-VIII should be storedat 4°C. |
Biological Activity : | The potency per mg was tested and found to be 150 Units/mg. |
Human Virus Test : | The plasma is collected from donors with Hepatitis B vaccinated. Each unit of plasma has been tested for HBsAg, Anti-HIV-1/2 plus O and Anti-HCV by using the imported kits which are approved by Federal Drug Administration (FDA). |
Usage : | Creative BioMart"s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Publication : |
Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity. (2016)
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Gene Name : | F8 coagulation factor VIII, procoagulant component [ Homo sapiens ] |
Synonyms : | F8; coagulation factor VIII, procoagulant component; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; coagulation factor VIII; factor VIII F8B; coagulation factor VIIIc; antihemophilic factor |
Gene ID : | 2157 |
mRNA Refseq : | NM_000132 |
Protein Refseq : | NP_000123 |
MIM : | 306700 |
UniProt ID : | P00451 |
Chromosome Location : | Xq28 |
Pathway : | Complement and coagulation cascades; Hemostasis |
Function : | copper ion binding; metal ion binding; oxidoreductase activity; protein binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionRecombinant DNA technology allows for the production of F8 protein in laboratory settings, reducing the risk of contamination and increasing availability.
Many patients can self-administer F8 protein therapy at home after proper training, providing convenience and improving overall quality of life.
Gene therapy is being explored as a potential alternative, aiming to introduce functional F8 genes into patients' cells to produce the missing protein.
Regular monitoring helps determine the appropriate dosage for replacement therapy, ensuring that F8 levels remain within the therapeutic range.
In some cases, individuals may develop inhibitors—antibodies that neutralize the therapeutic F8 protein—leading to challenges in treatment.
Customer Reviews (3)
Write a reviewThe F8 protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
With its consistent and outstanding results, the F8 protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
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