Human multidrug resistanec-associated protein 1
Cytoplasmic, Cell membrane
The MRP molecule, an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein, is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumours. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.
Formalin-fixed paraffin-embedded tissue, or IHC frozen sections. No antigen retrieval necessary.
IHC test, research use only. Incubate with samples at RT for 60min or at 4℃ overnight.
2-8℃ for 12 months.