Recombinant Rat Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1

• Cat.No.: Serpine1-5516R
• Product Overview: Recombinant RatSerpine1 typically contains 95% active PAI-1.

Specification

• Cat. No.: Serpine1-5516R
• Description: Serpine1 is a serineprotease inhibitor (serpin) that functions as the principal inhibitor oftissue plasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (Serpine1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. Inaddition, protease nexin acts as an inhibitor of tPA and urokinase. Serpine1,however, is the main inhibitor of the plasminogen activators.
• Source: E. coli
• Species: Rat
• Form: Liquid in 0.05 Msodium acetate + 0.4 M NaCl + 1 mM EDTA, pH 5.0.
• Molecular Weight: 43.0 kDa
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: Serpine1
• Pathways: Adipogenesis; BloodClotting Cascade; Chagas disease (American trypanosomiasis); Complement andCoagulation Cascades; Dissolution of Fibrin Clot; Hemostasis; Plateletactivation; Platelet degranulation; Response to elevated platelet cytosolicCa2+; Senescence and Autophagy; TGF Beta Signaling Pathway; p53 pathway; p53signaling pathway

Gene Information

• Gene Name: Serpine1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Rattus norvegicus ]
• Synonyms: Serpine1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; Pai1; PAI1A; Planh; Pai1aa; RATPAI1A; plasminogen activatorinhibitor 1; PAI; PAI-1; serpin E1; endothelial plasminogen activator inhibitor;serine (or cysteine) proteinase inhibitor, member 1; serine (or cysteine)peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinaseinhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor,clade E (nexin, plasminogen activator inhibitor type 1), member 1
• Gene ID: 24617
• mRNA Refseq: NM_012620
• Protein Refseq: NP_036752
• UniProt ID: P20961
• Chromosome Location: 12q11-q12
• Function: peptidase inhibitoractivity; protease binding; receptor binding; contributes to receptorbinding; serine-type endopeptidase inhibitor activity

Reviews

06/02/2022

It has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

07/16/2021

When used for experiments, the experimental conditions and results are highly repeatable.

02/28/2021

SERPINE1 has good solubility and is easy to operate and purify.

Q&As

Are there any gene polymorphisms or mutations in SERPINE1, and how do these mutations affect function?

Yes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.

What are the potential therapeutic applications of SERPINE1 inhibitors or activators?

Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.

How does SERPINE1 affect apoptosis and repair of nerve cells?

SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.

What are the new directions or breakthroughs in the study of SERPINE1 and its related molecular mechanisms in future research?

The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.

Are there other inhibitors or activators in the SERPINE1?

In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.

How is SERPINE1 related to Alzheimer's disease?

In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.