Native Human Sex Hormone-Binding Globulin

• Cat.No.: SHBG-5519H
• Product Overview: Native human SHBG wasexpressed in Human pregnancy plasma,which having a molecule weight of80 kDa.

Specification

• Description: SHBG or sexsteroid-binding globulin (SSBG) is a glycoprotein that binds to sex hormones,to be specific, testosterone and estradiol. Other steroid hormones such asprogesterone, cortisol, and other corticosteroids are bound by transcortin. Testosteroneand estradiol circulate in the bloodstream, bound mostly to SHBG and to somedegree bound to serum albumin. Only a small fraction is unbound and thus biologically active and able to enter a cell andactivate its receptor. The SHBG inhibits the function of these hormones.Thus, bioavailability of sex hormones is influenced by the level of SHBG.
• Source: Human pregnancyplasma
• Species: Human
• Form: Lyophilized from 0.1M Sodium Phosphate buffer, pH 7.4, without preservative.
• Molecular Mass: 80 kDa
• Purity: ≥98% asdetermined by SDS PAGE analysis
• Storage: Upon receipt storelyophilized at -20°C. Reconstituted product should also be stored at -20°C.Avoid repeated freeze-thaw cycles.
• Concentration: 1 mg/vial
• Reconstitution: Centrifuge vialprior to opening. Allow vial to warm to room temperature, then dissolve inlaboratory grade water or buffer. Do not use buffers containing divalentmetal ions (Ca2, Mg2, etc.)

Gene Information

• Gene Name: SHBG sex hormone-binding globulin [ Homo sapiens ]
• Official Symbol: SHBG
• Synonyms: SHBG; sex hormone-binding globulin; ABP; androgen binding protein; MGC126834; MGC138391; TEBG; sex steroid-binding protein; testosterone-binding beta-globulin; testosterone-estrogen-binding globulin; testosterone-estradiol-binding globulin; testis-specifi
• Gene ID: 6462
• mRNA Refseq: NM_001040
• Protein Refseq: NP_001031
• MIM: 182205
• UniProt ID: P04278
• Chromosome Location: 17pter-p12
• Pathway: Nongenotropic Androgen signaling, organism-specific biosystem
• Function: androgen binding; protein homodimerization activity