Native Human Apolipoprotein H (beta-2-glycoprotein I)

• Cat.No.: APOH-5365H
• Product Overview: Native human APOH was expressed in Human plasma.

Specification

• Description: APOH, also known asbeta2Glycoprotein-1 (B2GP-1) is a plasma glycoprotein that circulates at aconcentration of 200 ug/mL (4mM). B2GP-1 has been identified as a constituentof chylomicrons, very low density lipoproteins and high density lipoproteinsin Human plasma. It has also been demonstrated to bind phospholipids, heparinand platelets where it can modulate the activity of adenylate (19percent).Although the precise functions) are as yet unknown, B2GP-1 has been shown tointerfere with blood coagulation by competitively binding to phospholipidsexposed during cell activation or damage.
• Source: Human plasma
• Species: Human
• Form: Liquid in 0.02MTris-HCI+0.3M NaCI, pH 7.3.
• Molecular Mass: 48000
• Purity: ≥95% by SDS-PAGEanalysis
• Storage: When stored at -80°C product is stable for 3 years from date of delivery. Avoid repeated freeze-thawcycles.
• Concentration: 1.0 mg/ml

Gene Information

• Gene Name: APOH apolipoprotein H (beta-2-glycoprotein I) [ Homo sapiens ]
• Official Symbol: APOH
• Synonyms: APOH; apolipoprotein H (beta-2-glycoprotein I); B2G1; beta-2-glycoprotein 1; beta 2 glycoprotein I; BG; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein; B2GP1
• Gene ID: 350
• mRNA Refseq: NM_000042
• Protein Refseq: NP_000033
• MIM: 138700
• UniProt ID: P02749
• Chromosome Location: 17q23-qter
• Function: eukaryotic cell surface binding; glycoprotein binding; heparin binding; lipid binding; lipoprotein lipase activator activity; phospholipid binding; protein binding

Reviews

08/03/2021

the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.

08/27/2018

They actively engage with the scientific community, staying up-to-date with the latest advancements related to APOH protein and sharing this valuable information.

12/14/2016

This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.

05/15/2016

To summarize, the APOH protein provided by the manufacturer is of exceptional quality and perfectly aligns with my experimental requirements.

Q&As

Can the APOH protein influence blood clotting?

Yes, the APOH protein has anticoagulant properties. It inhibits the formation of blood clots by interacting with several components involved in the coagulation cascade, such as phospholipids and negatively charged surfaces.

Is there any association between APOH protein and cardiovascular diseases?

Yes, alterations in APOH protein levels and function have been observed in cardiovascular diseases, including atherosclerosis and coronary artery disease. Dysregulated lipid metabolism and impaired clotting control contribute to these associations.

How is the APOH protein linked to thrombosis?

Certain antibodies against the APOH protein are associated with the development of antiphospholipid syndrome (APS), an autoimmune disorder characterized by an increased risk of blood clot formation. These antibodies can disrupt the balance of normal blood coagulation.

Can the APOH protein be targeted for therapeutic interventions?

Targeting the APOH protein is a potential therapeutic strategy, especially for conditions like thrombosis, autoimmune diseases, and dyslipidemia. Developing drugs or interventions that modulate its function or expression may offer benefits in managing these diseases.

Are there any ongoing research studies investigating the APOH protein?

Yes, ongoing research studies are examining the role of APOH protein in various diseases, exploring its mechanisms of action, and investigating its potential as a therapeutic target. These studies aim to better understand its significance and explore new treatment avenues.

How does the APOH protein regulate lipid metabolism?

The APOH protein interacts with lipoproteins, such as high-density lipoprotein (HDL), to facilitate the transport and clearance of cholesterol from peripheral tissues. It helps in maintaining the balance of lipids in the bloodstream.

Can the APOH protein be used as a biomarker for certain diseases?

Yes, elevated levels of APOH protein have been detected in various pathological conditions, including autoimmune diseases and certain cancers. Therefore, it could serve as a potential biomarker for disease diagnosis or prognosis.

What are the consequences of APOH protein deficiency in the body?

APOH protein deficiency can lead to an increased risk of developing thrombotic disorders, such as deep vein thrombosis (DVT) and recurrent miscarriages in women. It can also contribute to autoimmune diseases and cardiovascular complications.

Where is the APOH protein produced in the body?

The APOH protein is primarily produced in the liver, but it is also synthesized and secreted by other tissues, such as the endothelial cells and the placenta.

How is the APOH gene regulated in the body?

The expression of the APOH gene is regulated by various factors, including transcription factors, hormones, and inflammatory mediators. Specific DNA sequences within the gene promoter region interact with these regulators to control gene expression.

Are there any therapeutic implications of targeting the APOH protein?

Due to its involvement in lipid metabolism, coagulation, and immune regulation, targeting the APOH protein may hold therapeutic potential for treating disorders such as dyslipidemia, thrombosis, and autoimmune diseases. Further research is necessary to explore its therapeutic applications.

Does the APOH protein have any role in autoimmune diseases?

The APOH protein has been implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Some antibodies against APOH have been observed in individuals with SLE and may contribute to disease development.

What are the functions of the APOH protein?

The APOH protein has multiple functions, including regulating lipid metabolism, inhibiting blood clotting, and modulating immune responses. It also functions as a cofactor for various molecular interactions.

Can dietary factors affect the APOH protein levels?

Yes, dietary factors, such as omega-3 fatty acids, have been shown to modulate the expression and function of the APOH protein. Consumption of certain nutrients can influence lipid metabolism and potentially impact APOH protein levels.

Does the APOH protein have any interactions with other proteins in the body?

Yes, the APOH protein interacts with various proteins, including clotting factors, lipoproteins, receptors, and immune molecules. These interactions are essential for its functional roles in lipid metabolism, coagulation, and immune regulation.

Can genetic mutations in the APOH gene lead to diseases?

Yes, certain genetic mutations in the APOH gene have been associated with an increased risk of developing autoimmune diseases, thrombosis-related disorders, and cardiovascular diseases.