| Cat. No. : |
Fcgr3-488M |
| Description : |
Receptors for the Fcregion of IgG (Fc γ Rs) are members of the Ig superfamily that function in theactivation or inhibition of immune responses such as degranulation, phagocytosis,ADCC (antibodydependent cellular toxicity), cytokine release, and B cell proliferation.The Fc γ Rs have been divided into three classes based on close relationshipsin their extracellular domains; these groups are designated Fc γ RI (also knownas CD64),The coordinated functioning of activating and inhibitory receptors isnecessary for successful initiation, amplification, and termination of immuneresponses. Mouse CD16 is encoded by a single gene. The protein product is a typeI transmembrane protein having two extracellular Iglike domains. It is expressedon a variety of myeloid and lymphoid cells and associates with Fc Rγ to deliveran activating signal upon ligand binding. Mouse CD32 is closely related to mouseCD16 throughout its extracellular domain (95% amino acid sequence identity), buthas a divergent cytoplasmic domain and functions as an inhibitory receptor. Togetherthese proteins constitute an activating/inhibiting receptor pair to regulate immuneresponses. |
| Source : |
Mammalian cells |
| Form : |
Supplied as a 0.2 μmfiltered solution in PBS. |
| N-terminal Sequence : |
Ala31 |
| Molecular Weight : |
22.5 kDa |
| Activity : |
Measured by its abilityto bind mouse IgG with an estimated KD < 15 nM. |
| Purity : |
>95%, by SDSPAGEunder reducing conditions and visualized by silver stain. |
| Endotoxin Level : |
<1.0 EU per 1 μg ofthe protein by the LAL method. |
| Storage : |
Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution. |
| OfficialSymbol : |
Fcgr3 |
