Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Antibody > Monoclonal Antibodies > Rabbit Anti-Mouse Cystatin C Monoclonal Antibody

Rabbit Anti-Mouse Cystatin C Monoclonal Antibody

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GST(1)
His(20)
N/A(9)
Cat.No.:
CAB11520RM
Product Overview:
Rabbit Monoclonal Antibody to Mouse Cystatin C
Antigen Description:
Mouse Cystatin-C, also known as Cystatin-3, Neuroendocrine basic polypeptide, Post-gamma-globulin, and CST3, is a secreted type 2 cysteine proteinase inhibitors of the cystatin superfamily, and exerts actions on a variety of cysteine proteases including papain and Cathepsins B, H, K, L and S. As the most abundant extracellular inhibitor of cysteine proteases, Cystatin-C encoded by a housekeeping gene is found ubiquitously in all organs and biological fluids at high concentration levels. It has been shown that Cystatin-C binds amyloid-beta and reduces cerebral amyloid-beta deposition or inhibits its fibril formation in an APP-transgenic mouse model. Thus, a point mutation in this gene (Leu 68 to Gln) hsa been associated with a severe hereditary form of amyloid angiopathy. Studies have also investigated Cystatin-C as a marker of kidney function and thyroid dysfunction prior to creatinine, and could be a useful clinical tool to identify HIV-infected persons. In addition, Cystatin-C expression is up-regulated in malignance of certain tumor progression.
Specificity:
Mouse Cystatin C / CST3. No cross-reactivity in ELISA with Human CST3; Human HPRG; Human KNG1; Human cell lysate (293 cell line);
Immunogen:
Recombinant Mouse Cystatin C / CST3 Protein
Host:
Rabbit
Isotype:
Rabbit IgG
Species:
Mouse
Clone:
A042
Applications:
WB; ELISA
Dilution:
Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CST3 in WB.Using a DAB detection system, the detection limit for Mouse CST3 is approximately 0.5 ng/lane under non-reducing conditions and 0.25 ng/lane under reducing conditions.ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CST3. The detection limit for Mouse CST3 is approximately 0.00245 ng/well.
Preparation:
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Cystatin C / CST3
Format:
0.2 μm filtered solution in PBS with 5% trehalose
Storage:
This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70°C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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