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Mouse Monoclonal Antibody to Human Von Willebrand Factor C Domain Containing 2

Cat.No.: CAB11625MH
Product Overview: Mouse Monoclonal Antibody to Human Von Willebrand Factor C Domain Containing 2
Antigen Description: Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein which contains two VWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.
Specificity: Human VWC2. No cross-reactivity with human cell lysate ( 293 cell line ) in ELISA.
Immunogen: Recombinant Human VWC2 Protein
Host: Mouse
Isotype: Mouse IgG2a
Species: Human
Clone: 11B6C5
Applications: Western blot
Dilution: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human VWC2 in WB. Using a DAB detection system, the detection limit for Human VWC2 is approximately 4 ng/lane under non-reducing conditions and 50 ng/lane under reducing conditions.
Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human VWC2. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Format: 0.2 μm filtered solution in PBS with 5% trehalose
Storage: This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name: VWC2 von Willebrand factor C domain containing 2 [ Homo sapiens ]
Official Symbol: VWC2
Synonyms: VWC2; von Willebrand factor C domain containing 2; brorin; brain specific chordin like; PSST739; UNQ739; brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2; MGC131845;
Gene ID: 375567
mRNA Refseq: NM_198570
Protein Refseq: NP_940972
MIM: 611108
UniProt ID: Q2TAL6
Chromosome Location: 7p12.3-p12.2
Function: molecular_function;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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