Mouse Anti-Atg3 Monoclonal Antibody
Cat.No. : | DMABT-H17736 |
Product Overview : | Mouse Anti-Atg3 Monoclonal Antibody |
- Specification
- Gene Information
- Related Products
Antigen Description : | Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Microtubule-associated protein light chain4(LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of LC3 is cleaved by a cysteine protease-Atg4, to produce LC3-I, which is located in cytosolic fraction. LC3-I is activated by the E1-like enzyme Atg7 and forms a Atg7-LC3-I thioester. Atg7-LC3-I is transferred to Atg3 to form Atg3-LC3-I thioester. Atg3 is an E2-like enzyme that catalyzes the conjugation of LC3-I and phosphatidylethanolamine (PE) to form LC3-II. The LC3-II-PE conjugate is essential for binding tightly to autophagosomal membrane. |
Target : | Atg3 |
Host : | Mouse |
Isotype : | IgG2b |
species : | Human |
Clone : | 4F9 |
Conjugation : | N/A |
Applications : | WB,IP,ICC,IHC,Flow Cyt |
Storage : | -20°C |
Size : | 100 μg |
Ship : | 4°C |
Gene Name : | ATG3 ATG3 autophagy related4homolog (S. cerevisiae) [ Homo sapiens ] |
Official Symbol : | Atg3 |
Synonyms : | ATG3; ATG3 autophagy related4homolog (S. cerevisiae); APG3 autophagy4like (S. cerevisiae) , APG3L; ubiquitin-like-conjugating enzyme ATG3; DKFZp564M1178; FLJ22125; MGC15201; PC3 96; hApg3; 2610016C12Rik; autophagy-related protein 3; APG3; APG3L; PC3-96; APG3-LIKE; |
Gene ID : | 64422 |
mRNA Refseq : | NM_022488 |
Protein Refseq : | NP_071933 |
MIM : | 609606 |
UniProt ID : | Q9NT62 |
Chromosome Location : | 3q13.2 |
Pathway : | Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem; |
Function : | Atg12 ligase activity; Atg8 ligase activity; enzyme binding; ligase activity; protein binding; small conjugating protein ligase activity; |
Products Types
◆ Recombinant Protein | ||
ATG3-269R | Recombinant Rhesus Macaque ATG3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ATG3-825M | Recombinant Mouse ATG3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ATG3-396H | Recombinant Human ATG3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ATG3-500R | Recombinant Rat ATG3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Atg3-1759M | Recombinant Mouse Atg3 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
ATG3-8625HCL | Recombinant Human ATG3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket