Native Cow TRIM21
Cat.No. : | TRIM21-212B |
Product Overview : | Cow full length TRIM21 was purified from Bovine thymus tissue. |
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Cat. No. : | TRIM21-212B |
Description : | A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B (''Thr-187'' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. |
Source : | Bovine thymus tissue |
Molecular Mass : | 54kDa |
Formulation : | Liquid |
Purity : | >90% as determined by SDSPAGE |
Storage buffer : | Constituents: 20% Glycerol, 0.1% Micr-O-protect |
Applications : | ELISA; SDS-PAGE |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -20ºC. Avoid freeze / thaw cycles. |
OfficialSymbol : | TRIM21 |
Gene Name : | TRIM21 tripartite motif containing 21 [ Bos taurus ] |
Synonyms : | E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; 52kD Ro/SSA autoantigen; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A |
Gene ID : | 359715 |
mRNA Refseq : | NM_182655 |
Protein Refseq : | NP_872596 |
UniProt ID : | Q7YRV4 |
Chromosome Location : | 15 |
Pathway : | Systemic lupus erythematosus |
Function : | DNA binding; RNA binding; ubiquitin-protein ligase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
TRIM21-4768R | Recombinant Rhesus Macaque TRIM21 Protein, His (Fc)-Avi-tagged | +Inquiry |
Trim21-6646M | Recombinant Mouse Trim21 Protein, Myc/DDK-tagged | +Inquiry |
TRIM21-671H | Recombinant Human TRIM21 Protein (Met1-Tyr475), His-tagged | +Inquiry |
TRIM21-11H | Recombinant Human TRIM21 Protein (1-475), C-His-tagged | +Inquiry |
TRIM21-2685H | Recombinant Human TRIM21 protein(81-260 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
TRIM21-791HCL | Recombinant Human TRIM21 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTRIM21 has demonstrated efficacy against a broad range of viruses, including but not limited to influenza, herpes simplex virus, and adenovirus.
TRIM21 acts as an intracellular antibody receptor, binding to antibodies that have attached to viruses inside the cell. This binding triggers a process that leads to the destruction of the virus.
TRIM21 has promising applications in various clinical settings, particularly in the development of therapies for viral infections and autoimmune diseases.
TRIM21's role in regulating immune responses makes it a potential target for therapies aimed at modulating the immune system in autoimmune diseases.
Yes, TRIM21's ability to target and degrade antibody-bound viruses makes it a potential candidate for antiviral therapies.
Customer Reviews (3)
Write a reviewThey can provide fast and efficient delivery services, minimizing any potential delays and allowing researchers to proceed with their studies in a timely manner.
The manufacturer can provide researchers with a high-quality, purified form of TRIM21 protein, ensuring its integrity and functionality for experimental use.
A manufacturer with a responsive and dedicated customer support team can address any concerns or queries that researchers may have.
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