Recombinant Human WNT3A, His-tagged

• Cat.No.: WNT3A-1698H
• Product Overview: Recombinant Human WNT3A (19-120aa) was expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose.

Specification

• Cat. No.: WNT3A-1698H
• Description: Wingless-type MMTV integration site family, member 3A, also known as WNT3A is an intercellular signaling molecule. WNT3A is expressed extensively in cells fated to give rise to embryonic mesoderm. Wnt-3a regulates survival, expansion, and maintenance of neural progenitors derived from embryonic stem cells. It has been reported that Wnt-3a supports self-renewal of embryonic stem cells and can maintain these cells in a pluripotent state. Wnt-3a is also considered a ligand that activates the beta-catenin-dependent pathway in Wnt signaling, which is implicated in numerous physiological events such as morphogenesis.
• Source: E.coli
• Storagebuffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
• Storage: The protein is stored in PBS buffer at -20 oC. Repeated freezethaw cycles should be avoided.
• OfficialSymbol: WNT3A

Gene Information

• Gene Name: WNT3A wingless-type MMTV integration site family, member 3A [ Homo sapiens ]
• Synonyms: wingless-type MMTV integration site family, member 3A; MGC119418; MGC119419; MGC119420; WNT3A; OTTHUMP00000035713
• Gene ID: 89780
• mRNA Refseq: NM_033131
• Protein Refseq: NP_149122
• MIM: 606359
• UniProt ID: P56704
• Chromosome Location: 1q42
• Pathway: Basal cell carcinoma; Hedgehog signaling pathway; Melanogenesis; Pathways in cancer; Wnt signaling pathway
• Function: extracellular matrix structural constituent; protein binding; signal transducer activity