"HIST1H1A" Related Products

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Mouse Anti-HisT1H1A Monoclonal Antibody

Cat.No.: DMABT-H16577
Product Overview: Mouse Anti-HIST1H1A Monoclonal Antibody
Antigen Description: Histone H1 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. A variant of the histone H1 protein is the histone H5, which has a similar structure and function, but is only found in avian erythrocytes, which unlike mammals have nuclei. Featuring a central globular domain and long C and N terminal tails H1 is involved with the packing of the "beads on a string" structure into the "30nm solenoid" structure. H1 is present in half the amount of the other four histones. This is because unlike the other histones, H1 does not make up the nucleosome "bead". Instead, it sits on top of the structure, keeping in place the DNA that has wrapped around the nucleosome. Specifically, the H1 protein binds to the linker DNA (approximately 80 nucleotides in length); region between the histone beads, helping stabilize the zig-zagged 30nm chromatin fiber. H1 histone seals off the nucleosome at the location at which the linker DNA enters and leaves.
specificity: Anti-Human Histone H1 recognizes an antigen associated with Human Histone H1 in the nucleaus of animals and plants. The sequence of the epitope is unmapped.
Target: HIST1H1A
Host: Mouse
Isotype: Mouse IgG2a
species: Human
Clone: BF5
Conjugation: N/A
Applications: N/A
Storage: For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Size: 2.0 ml
Gene Name: HIST1H1A histone cluster 1, H1a [ Homo sapiens ]
Official Symbol: HIST1H1A
Synonyms: HIST1H1A; histone cluster 1, H1a; H1 histone family, member2, H1F1, histone 1, H1a; histone H1.1; H1.1; H1a; histone 1, H1a; H1 histone family, member 1; H1A; H1F1; HIST1; MGC126642; MGC138345;
Gene ID: 3024
mRNA Refseq: NM_005325
Protein Refseq: NP_005316
MIM: 142709
UniProt ID: Q02539
Chromosome Location: 6p22.1
Pathway: Activation of DNA fragmentation factor, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;
Function: DNA binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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