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Rat Anti-Havcr1 Monoclonal Antibody

Cat.No.: DMAB36385
Product Overview: Rat Anti-Havcr1 Monoclonal Antibody
Antigen Description: Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity.
specificity: It specifically recognises mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b).
Target: Havcr1
Immunogen: Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
Host: Rat
Isotype: IgG2a
species: Mouse
Clone: SNU2-20
Purification: Purified IgG
Conjugation: RPE
Applications: Flow Cyt
Dilution: Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Reconstitution: Reconstitute with 1.0 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial.
Storage: Prior to reconstitution store at +4°C. After reconstitution store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Preservative: 0.09% Sodium Azide (NaN3),1% Bovine Serum Albumin,5% Sucrose
Shelf life: 12 months from date of reconstitution.
Size: 100 TESTS
Gene Name: Havcr1 hepatitis A virus cellular receptor 1 [ Mus musculus ]
Official Symbol: Havcr1
Synonyms: HAVCR1; hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; TIMD-1; HAVcr-1; kidney injury molecule 1; t cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; t cell immunoglobulin and mucin domain-containing protein 1; Tim1; KIM-1; TIM-1; Timd1; AI503787;
Gene ID: 171283
mRNA Refseq: NM_001166631
Protein Refseq: NP_001160103
Function: receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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