Recombinant Human Fas (TNF receptor superfamily, member 6)
Cat.No. : | FAS-3814H |
Product Overview : | A DNA sequence encoding the extracellular domain (Met 1-Glu 173) of human Fas antigen (NP_000034.1) was fused with the Fc region of human IgG1 at the C-terminus. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FAS-3814H |
Description : | FAS is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily. FAS is highly expressed on the surface of a number of cell types including epithelial cells, hepatocytes, activated mature lymphocytes and other tumor cells. This receptor contains a death domain and has been shown to play a central role in the physiological regulation of programmed cell death (PCD, apoptosis) upon ligation of Fas ligand (Fas-L). |
Source : | Human |
Host : | Human Cells |
Form : | Lyophilized from sterile PBS, pH 7.4, Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Purity : | > 95 % as determined by SDS-PAGE |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70°C. |
Predicted N terminal : | Gln 26 |
Molecular Mass : | The recombinant human FAS chimera is a disulfide-linked homodimeric protein generated after removal of the signal peptide. The reduced monomer consists of 386 amino acids and has a predicted molecular mass of 43.4 kDa. In SDS-PAGE under reducing conditions, the monomer migrates as an approximately 55-60 kDa protein due to glycosylation. |
Storage : | Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] |
Official Symbol : | FAS |
Synonyms : | FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily member 6; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000217569; apoptosis antigen 1; APO-1 cell surface antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6 |
Gene ID : | 355 |
mRNA Refseq : | NM_000043 |
Protein Refseq : | NP_000034 |
MIM : | 134637 |
UniProt ID : | P25445 |
Chromosome Location : | 10q24 |
Pathway : | Adipogenesis; African trypanosomiasis; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Death Receptor Signalling; Direct p53 effectors; FasL/CD95L signaling; Influenza A; MAPK signaling pathway; Measles; Natural killer cell mediated cytotoxicity; Pathways in cancer; Type I diabetes mellitus; p53 signaling pathway |
Function : | binding; kinase binding; protein binding; receptor activity; signal transducer activity; transmembrane signaling receptor activity; tumor necrosis factor receptor activity |
Products Types
◆ Recombinant Protein | ||
Fas-12R | Recombinant Rat Fas Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-258C | Recombinant Cynomolgus Monkey FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-3851H | Recombinant Human FAS Protein, His/Flag/StrepII-tagged | +Inquiry |
FAS-3853H | Recombinant Human FAS Protein, GST-tagged | +Inquiry |
FAS-242H | Recombinant Human FAS Protein, His-tagged | +Inquiry |
◆ Lysates | ||
FAS-001CCL | Recombinant Cynomolgus FAS cell lysate | +Inquiry |
FAS-1139RCL | Recombinant Rat FAS cell lysate | +Inquiry |
FAS-2419MCL | Recombinant Mouse FAS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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