| Cat. No. : |
Slamf7-4018M |
| Description : |
Mouse SLAM family member 7, also known as CRACC, SLAMF7, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B- cell lines, or T-cell lines. The cytoplasmic domain of SLAMF7 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/ SH2D1A). SLAMF7 may play a role in the regulation of B lymphocyte proliferation during immune responses. SLAMF7 is implicated in the activation of NK cell-mediated cytotoxicity. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. In the absence of EAT-2, SLAMF7 potently inhibited natural killer cell function. |
| Source : |
Mouse |
| Host : |
Human Cells |
| Form : |
Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
| Purity : |
> 95 % as determined by SDS-PAGE. |
| Bio-activity : |
Measured by its ability to bind biotinylated mouse SLAMF7 in a functional ELISA |
| Endotoxin : |
< 1.0 EU per μg of the protein as determined by the LAL method. |
| Stability : |
Samples are stable for up to twelve months from date of receipt at -70μ |
| Predicted N terminal : |
Ser 23 |
| Molecular Mass : |
The recombinant mouse SLAMF7 consists of 213 amino acids with the predicted molecular mass of 23.7 kDa. As a result of glycosylation, the apparent molecular mass of rm SLAMF7 is approximately 35-50 kDa in SDS-PAGE under reducing conditions. |
| Storage : |
Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
