Recombinant Human TARDBP, GST-tagged

• Cat.No.: TARDBP-4735H
• Product Overview: Recombinant Human TARDBP(1 a.a. - 260 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.

Specification

• Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
• Source: Wheat germ
• Species: Human
• Tag: GST
• Molecular Mass: 54.34 kDa
• AA Sequence: MSEYIRVTEDENDEPIEIPSEDDGT VLLSTVTAQFPGACGLRYRNPVSQC MRGVRLVEGILHAPDAGWGNLVYVV NYPKDNKRKMDETDASSAVKVKRAV QKTSDLIVLGLPWKTTEQDLKEYFS TFGEVLMVQVKKDLKTGHSKGFGFV RFTEYETQVKVMSQRHMIDGRWCDC KLPNSKQSQDEPLRSRKVFVGRCTE DMTEDELREFFSQYGDVMDVFIPKP FRAFAFVTFADDQIAQSLCGEDLII KGISVHISNA
• Applications: ELISA; WB-Re; AP; Array
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens (human) ]
• Official Symbol: TARDBP
• Synonyms: TARDBP; TDP-43; TAR DNA binding protein; ASL 10; TAR DNA-binding protein 43; TDP43; TAR DNA-binding protein 43; OTTHUMP00000002173; TRA DNA-binding protein-43
• Gene ID: 23435
• mRNA Refseq: NM_007375
• Protein Refseq: NP_003140
• MIM: 605078
• UniProt ID: Q13148
• Chromosome Location: 1p36.22
• Function: RNA binding; double-stranded DNA binding; mRNA 3'-UTR binding; nucleotide binding; protein binding; sequence-specific DNA binding transcription factor activity

Reviews

10/19/2021

There is no interaction with other reagents, and there is no influence.

07/10/2021

The catalytic activity is very good, and the catalytic performance can be maintained in any environment.

09/22/2020

TARDBP has good solubility and can be easily dissolved in a variety of buffers.

Q&As

How does TARDBP affect the growth and survival of neurons?

TARDBP may influence the growth and survival of neurons by regulating processes such as protein synthesis and intracellular transport. It may also be involved in regulating neuronal signaling and synaptic function.

Does the structure of TARDBP relate to its function?

The structure of TARDBP determines its ability to bind to RNA and its interaction with ribosomes and other molecules. The study of its structure can help us understand its function and mechanism of action.

Is it possible to treat disease by modulating TARDBP expression?

There are currently no therapies that directly regulate TARDBP expression. However, its function and interacting molecules can be studied to understand its mechanism of action and discover potential treatments.

What is the function of TARDBP in the nervous system?

In the nervous system, TARDBP may be involved in the development and function of neurons. Studies have shown that its expression levels are associated with neurological disorders such as ALS and FTD.

Can TARDBP expression be regulated?

The expression level of TARDBP can be regulated in a variety of ways, including transcription, post-transcriptional modification, and degradation. These processes may involve various molecules such as transcription factors, regulatory Rnas, and signal transduction pathways.

How is the expression level of TARDBP associated with disease?

Studies have shown that TARDBP expression levels are associated with certain neurological diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases may be related to the abnormal function of TARDBP.