Recombinant Human MAP/Microtubule Affinity-Regulating Kinase 2, GST-tagged
Cat.No. : | MARK2-1057H |
Product Overview : | Recombinant full-length human MARK2 was expressed by baculovirus in Sf9 insect cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MARK2-1057H |
Description : | MARK2 or microtubule affinity-regulating kinase 2 is a member of the Par-1 family of serine/threonine protein kinases. MARK2 is an important regulator of cell polarity in epithelial and neuronal cells and controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins (1). MARK2 is a key target of H. pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation, and carcinogenesis (2). MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. MARK2 function in the establishment of T cell polarity following engagement to an APC. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 114 kDa |
Expression System : | Sf9 insect cells using baculovirus. |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 795 nmol/min/mg |
Purity : | > 70% |
Concentration : | 0.1 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | LKB1 signaling events; Notch signaling pathway; TNF-alpha/NF-kB Signaling Pathway; Wnt Signaling Pathway NetPath |
Gene Name : | MARK2 MAP/microtubule affinity-regulating kinase 2 [ Homo sapiens ] |
Official Symbol : | MARK2 |
Synonyms : | MARK2; MAP/microtubule affinity-regulating kinase 2; EMK1; EMK-1; PAR-1; Par1b; MGC99619; serine/threonine-protein kinase MARK2; PAR1 homolog; OTTHUMP00000218338; OTTHUMP00000218339; OTTHUMP00000218340; OTTHUMP00000218343; OTTHUMP00000236749; OTTHUMP00000236750; OTTHUMP00000236758; OTTHUMP00000237224; ELKL motif kinase 1; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; EC=2.7.11.1; PAR1 homolog |
Gene ID : | 2011 |
mRNA Refseq : | NM_001039469 |
Protein Refseq : | NP_001034558 |
MIM : | 600526 |
UniProt ID : | Q7KZI7 |
Chromosome Location : | 11q13.1 |
Function : | ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity |
Products Types
◆ Recombinant Protein | ||
Mark2-3960M | Recombinant Mouse Mark2 Protein, Myc/DDK-tagged | +Inquiry |
MARK2-5373M | Recombinant Mouse MARK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MARK2-3245R | Recombinant Rat MARK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MARK2-3525H | Recombinant Human MARK2 protein, His-tagged | +Inquiry |
MARK2-9568M | Recombinant Mouse MARK2 Protein | +Inquiry |
◆ Lysates | ||
MARK2-1060HCL | Recombinant Human MARK2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket