Recombinant Human Sirtuin 2, GST-tagged
Cat.No. : | SIRT2-4876H |
Product Overview : | Full-length recombinant human SIRT2 was expressed in E. coli cells using an N-terminal GST tag. |
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Cat. No. : | SIRT2-4876H |
Description : | SIRT2 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT2 being a member of class I. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington" s disease. Huntington"s disease is characterized by increased sterol synthesis in neuronal cells and this process is reversed by SIRT2 inhibition. |
Applications : | Western Blot |
Molecular Weight : | 64 kDa |
Expression System : | E. coli |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
Purity : | > 85 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Signaling events mediated by HDAC Class I; Signaling events mediated by HDAC Class III |
Gene Name : | SIRT2 sirtuin 2 [ Homo sapiens ] |
Official Symbol : | SIRT2 |
Synonyms : | SIRT2; sirtuin 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; OTTHUMP00000197460; OTTHUMP00000197461; OTTHUMP00000197465; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; EC 3.5.1.-; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 2 |
Gene ID : | 22933 |
mRNA Refseq : | NM_012237 |
Protein Refseq : | NP_036369 |
MIM : | 604480 |
UniProt ID : | Q8IXJ6 |
Chromosome Location : | 19q13 |
Function : | NAD binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding; protein binding; protein deacetylase activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSIRT2 is involved in stress response pathways, deacetylating and modulating the activity of stress-responsive proteins, contributing to cellular adaptation to various stress conditions.
SIRT2 influences cellular metabolism by deacetylating enzymes involved in glycolysis, fatty acid metabolism, and mitochondrial function, impacting overall energy homeostasis.
SIRT2 uses NAD+ as a cofactor to remove acetyl groups from lysine residues, a process that links cellular metabolic state to protein acetylation and deacetylation.
SIRT2 influences cell cycle progression by deacetylating key regulators, such as cyclin-dependent kinases (CDKs) and checkpoint proteins, impacting cell cycle checkpoints and progression.
SIRT2 has been implicated in neurodegenerative diseases, and modulating its activity is explored as a potential therapeutic strategy for conditions such as Parkinson's disease.
Customer Reviews (3)
Write a reviewEfficient and knowledgeable customer service—made our purchase straightforward.
This recombined protein is our go-to for dependable and accurate results.
Punctual delivery is crucial, and this product arrived right on time.
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