Recombinant Human Inhibin, Beta A, His-tagged

Cat. No.

INHBA-5059H

Product Overview

Recombinant human INHBA was expressed in Nicotiana benthamiana and purified by using conventional chromatography techniques.

Description

Activin A is a TGF beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF beta antagonist, Follistatin.

Concentration

50 ng/ul

Source

Human

Host

Nicotiana benthamiana

Form

Lyophilized from 50mM Tris HCl at pH 7.4.

Purity

> 97% by SDS - PAGE gel

Sequence

HHHHHHGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Molecular Mass

13.7 kDa beta A single chain, containing 116 amino residues

Applications

Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions.

Endotoxin Levels

<0.04 EU/ug protein (LAL method)

Storage

Aliquot and store at -20 deg C. Avoid repeated freeze/thaw Cycles

Antigen Gene Information

Gene Name

INHBA inhibin, beta A [ Homo sapiens ]

Official Symbol

INHBA

Synonyms

A-inhibin subunit; inhibin alpha subunit; inhibin, alpha; INHA; Inhibin A; Inhibin isoform A

GeneID

3624

mRNA Refseq

NM_002192

Protein Refseq

NP_002183

MIM

147290

UniProt ID

P08476

Chromosome Location

7p15-p13

Pathway

ALK1 signaling events; Cytokine-cytokine receptor interaction; Senescence and Autophagy; TGF Beta Signaling Pathway

Function

cytokine activity; follistatin binding; growth factor activity; hormone activity; identical protein binding; signal transducer activity