Recombinant Human Microtubule-Associated Protein Tau, His-tagged
Cat.No. : | MAPT-5074H |
Product Overview : | Recombinant human Tau protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. |
- Specification
- Gene Information
- Related Products
- Download
Cat. No. : | MAPT-5074H |
Description : | Tau, also known as microtubule-associated protein tau (MAPT), is a protein that stabilizes microtubules. It is abundant in neurons in the central nervous system and is less common elsewhere. When this protein is defective, and no longer stabilizes microtubules properly, it can result in dementias, such as Alzheimer"s disease. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl. |
Purity : | > 90% by SDS - PAGE |
Sequence : | 1-383 amino acids: MGSSHHHHHH SSGLVPRGSH MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKAEEAGI GDTPSLEDEA AGHVTQARMV SKSKDGTGSD DKKAKGADGK TKIATPRGAA PPGQKGQANA TRIPAKTPPA PKTPPSSGEP PKSGDRSGYS SPGSPGTPGS RSRTPSLPTP PTREPKKVAV VRTPPKSPSS AKSRLQTAPV PMPD |
Molecular Mass : | 42.1 kDa (403aa) confirmed by MALDI-TOF (molecular size on SDS-PAGE will appear higher) |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | MAPT microtubule-associated protein tau [ Homo sapiens ] |
Official Symbol : | MAPT |
Synonyms : | MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; MGC138549; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1 |
Gene ID : | 4137 |
mRNA Refseq : | NM_001123066 |
Protein Refseq : | NP_001116538 |
MIM : | 157140 |
UniProt ID : | P10636 |
Chromosome Location : | 17q21.1 |
Pathway : | Alzheimer"s disease; MAPK signaling pathway; Apoptosis |
Function : | axon; cell projection; cytoplasm; cytoskeleton; growth cone; microtubule; microtubule associated complex; plasma membrane; tubulin complex |
Products Types
◆ Recombinant Protein | ||
MAPT-2888H | Recombinant Human MAPT protein(1-441 aa, Tau231), C-His-tagged | +Inquiry |
MAPT-01C | Recombinant Cynomolgus MAPT Protein, His tagged | +Inquiry |
MAPT-120H | Recombinant Human p-Tau181 Protein | +Inquiry |
MAPT-2889H | Recombinant Human MAPT protein(1-441 aa, Tau181), C-His-tagged | +Inquiry |
MAPT-39H | Recombinant Human MAPT Protein (216-391), N-AVI-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
MAPT-4477HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
MAPT-4476HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
MAPT-4478HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe degree of abnormal aggregation of MAMAP proteins can be assessed by a variety of methods, such as immunohistochemistry, immunofluorescence staining, Western blot, etc. These methods can detect and quantify abnormally aggregated MAPT proteins.
The MAPT protein is closely related to the nerve cytoskeleton. It is involved in regulating axon formation and maintenance, cytosolic flow, and the normal function of neurons by binding and stabilizing microtubules.
MAPT protein interacts with other proteins in the nervous system, such as α-synuclein, β-kinigin, etc. These interactions may be involved in regulating the structure and function of neurons.
Yes, the expression of MAPT protein is affected by a variety of regulatory mechanisms, including transcriptional regulation, splicing regulation, phosphorylation regulation, etc. These regulatory mechanisms are essential for maintaining normal MAPT protein levels and function.
Future research directions include further elucidating the mechanism of abnormal aggregation and phosphorylation of MAPT protein, exploring the pathogenesis of genetic diseases associated with MAPT gene, finding therapeutic strategies to intervene in abnormal aggregation of MATT, and developing biomarkers related to MAPT protein for early diagnosis and therapeutic monitoring.
The MAPT protein plays an important role in clinical diagnosis. By measuring the level of the MAPT protein in the blood or cerebrospinal fluid, it can help identify different types of neurodegenerative diseases, such as Alzheimer's disease and prefrontal temporal dementia.
Customer Reviews (3)
Write a reviewWestern-blot experiments using MAPT as a target have shown highly reproducible results.
This stability of MAPT is very good and can maintain its original properties even after multiple uses.
MAPT's purity and consistency make it a top choice for Western-blot experiments.
Ask a Question for All MAPT Products
Required fields are marked with *
My Review for All MAPT Products
Required fields are marked with *
Inquiry Basket