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Home > Products > Recombinant Proteins > Recombinant Human ITGAV/ITGB3 Heterodimer Protein, His-tagged

Recombinant Human ITGAV/ITGB3 Heterodimer Protein, His-tagged

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His(7)
Human(3)
N/A(1)
Cat.No.:
ITGA5-101H
Product Overview:
Recombinant Human ITGAV(Phe 31 - Val 992)/ITGB3 (Gly 27 - Asp 718) Heterodimer Protein, Subunit ITGAV is fused with polyhistidine tag at the C-terminus and followed by a acidic tail and subunit ITGB3 contains no tag but a basic tail at the C-terminus was expressed in HEK293.
Description:
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Source:
HEK293
Species:
Human
Tag:
His
Predicted N Terminal:
The predicted N-terminus is Phe 31 (ITGAV) & Gly 27 (ITGB3)
Form:
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass:
Has a calculated MW of 113 kDa (ITGAV) and 81.8 kDa (ITGB3). The reducing (R) protein migrates as 145 kDa (ITGAV) and 100-116 kDa (ITGB3) respectively due to glycosylation.
Protein length:
ITGAV(Phe 31 - Val 992)/ITGB3 (Gly 27 - Asp 718)
Endotoxin:
Less than 1.0 EU per μg of the Human ITGAV & ITGB3 Heterodimer Protein by the LAL method.
Purity:
>95% as determined by SDS-PAGE.
Storage:
Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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