Active Native Human PLAU

• Cat.No.: PLAU-8456H
• Product Overview: LPA was purified from Human urine.

Specification

• Description: Urokinase (UK) is a serine protease, which is one of biological plasminogen activators. It is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. It can be obtained from human urine or kidney cell culture. UK is a two-chain glycoprotein containing 411 amino acids with 12 dissulfide bonds. Its molecular weight is 54,000.
• Source: Human
• Species: Human
• Form: Lyophilized powder
• Bio-activity: 1 nM UK will cause a change in absorbance of 0.001 at 405 nm in 1 minute at R/T in 100 μl reaction mixture containing 0.05 M Tris-HCl, 0.1 M NaCl, pH 7.4, using S2444 (0.6mM) as the substrate.
• Molecular Mass: 54.0 kDa
• Purity: ≥0% by SDS - PAGE; ≥0% by HPLC
• Storage: -20°C
• Reconstitution: Reconstitute in sterile H2O to a concentration >100 ug/ml. The solution can then be diluted into other aqueous solutions.
• Shipping: Gel pack

Gene Information

• Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens ]
• Official Symbol: PLAU
• Synonyms: PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK; U-plasminogen activator; plasminogen activator, urinary; ATF; QPD; u-PA; BDPLT5
• Gene ID: 5328
• mRNA Refseq: NM_001145031
• Protein Refseq: NP_001138503
• MIM: 191840
• UniProt ID: P00749
• Chromosome Location: 10q24
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Dissolution of Fibrin Clot, organism-specific biosystem
• Function: peptidase activity; protein binding; serine-type endopeptidase activity