Active Recombinant Human GPT
Cat.No. : | GPT-33H |
Product Overview : | Recombinant Human GPT was expressed in E.coli. |
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Cat. No. : | GPT-33H |
Description : | This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. |
Source : | E. coli |
Molecular Mass : | 54,479 of subunit deduced from gene sequence |
Form : | Liquid with Bufferized solution |
Purity : | Single major band visualized |
Activity : | Typically >1,000 u/mL |
Applications : | Calibrator/Control for ALT activity assay, Standard antigen for Immunoblotting, Standard antigen for ELISA. |
Storage : | -20 oC |
OfficialSymbol : | GPT |
Gene Name : | GPT glutamic-pyruvate transaminase (alanine aminotransferase) [ Homo sapiens ] |
Synonyms : | GPT; glutamic-pyruvate transaminase (alanine aminotransferase); AAT1; ALT1; GPT1; Alanine aminotransferase 1; Glutamic--pyruvic transaminase 1; Glutamate pyruvate transaminase 1; EC 2.6.1.2; glutamic pyruvate transaminase |
Gene ID : | 2875 |
mRNA Refseq : | NM_005309 |
Protein Refseq : | NP_005300 |
MIM : | 138200 |
UniProt ID : | P24298 |
Chromosome Location : | 8q24.3 |
Pathway : | Alanine, aspartate and glutamate metabolism; Alanine and aspartate metabolism; Metabolism; alanine biosynthesis II; Metabolism of amino acids |
Function : | L-alanine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding |
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◆ Native Protein | ||
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe GPT gene, encompassing GPT1 and GPT2, is pivotal in glucose and amino acid metabolism. GPT2 is notably linked to tumorigenesis in various cancers, while the involvement of GPT1 in cancer remains uncertain and requires further exploration.
The GPT gene encodes ALT1, a key enzyme in cellular metabolism. ALT1 facilitates the reversible transamination between alanine and 2-oxoglutarate, crucial for glucose and amino acid metabolism. Elevated serum ALT1 levels are commonly used as a biomarker for liver injury caused by drug toxicity, infection, alcohol, and steatosis.
SMS protein alone doesn't impact LSCC patient prognosis, but when combined with GPT, it shows significance. Inconsistency between SMS transcriptional and protein levels may stem from various factors, including the involvement of regulatory elements and different post-transcriptional and post-translational modifications.
Analysis of LSCC tissues and cell lines revealed an inverse relationship between GPT and SMS expressions, confirmed through qRT-PCR and TCGA data. GPT protein, primarily located in the epithelium, was down-regulated in LSCC tissues.
GPT gene expression serves as a marker for cancer-induced metabolic reprogramming in tissues, indicating shifts in energy metabolism and biosynthetic processes.
Customer Reviews (3)
Write a reviewFantastic customer support. They genuinely care about the success of our research.
Top-notch protein quality! It's our go-to for reliable and reproducible results.
Very happy with this lab product!
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