Active Recombinant Human SRSF1, His-tagged
Cat.No. : | SRSF1-8494H |
Product Overview : | Recombinant Human SRSF1, fused with His tag, was expressed in Sf21 Cells. |
- Specification
- Gene Information
- Related Products
Description : | ASF also known as SF2 is a member of the SR protein family. It is an essential pre-mRNA splicing factor required for both single and alternative splicing. Phosphorylation on serine residues located within the SR domain directly regulates ASF/SF2 activity and compartmentalization of other SR splicing factors. In addition to interacting with RNA and other splicing factors, such as U1-70K, U2AF and other SR proteins, ASF/SF2 also directly or indirectly interacts with HIV regulatory protein Rev, the C-terminal domain (CTD) of the largest subunit of RNA polymerase II, and numerous transcription factors, thereby suggesting a potential role of ASF/SF2 in coordinating transcription and pre-mRNA splicing . |
Source : | Sf21 Cells |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
Bio-activity : | 1 unit equals 1 ng of purified protein. 1-5 units are sufficient for a gel mobility shift assay in a 20 μl reaction, 100 units are sufficient for a protein-protein interaction assay and 100-500 units are required for a splicing assay in a 20 μl reaction. |
AA Sequence : | SGGGVIRGPA GNNDCRIYVG NLPPDIRTKD IEDVFYKYGA IRDIDLKNRR GGPPFAFVEF EDPRDAEDAV YGRDGYDYDG YRLRVEFPRS GRGTGRGGGG GGGGGAPRGR YGPPSRRSEN RVVVSGLPPS GSWQDLKDHM REAGDVCYAD VYRDGTGVVE FVRKEDMTYA VRKLDNTKFR SHEGETAYIR VKVDGPRSPS YGRSRSRSRS RSRSRSRSNS RSRSYSPRRS RGSPRYSPRH SRSRSRT |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 350 μg/ml |
Shipping : | Dry Ice |
Gene Name : | SRSF1 serine/arginine-rich splicing factor 1 [ Homo sapiens ] |
Official Symbol : | SRSF1 |
Synonyms : | SRSF1; serine/arginine-rich splicing factor 1; SFRS1, splicing factor, arginine/serine rich 1; alternate splicing factor; ASF; MGC5228; pre mRNA splicing factor SF2; P33 subunit; SF2; SF2p33; splicing factor 2; SR splicing factor 1; SRp30a; ASF-1; alternative-splicing factor 1; splicing factor, arginine/serine-rich 1; pre-mRNA-splicing factor SF2, P33 subunit; SFRS1; FLJ53078; |
Gene ID : | 6426 |
mRNA Refseq : | NM_006924 |
Protein Refseq : | NP_008855 |
MIM : | 600812 |
UniProt ID : | Q07955 |
Chromosome Location : | 17q22 |
Pathway : | Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; Gene Expression, organism-specific biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; RNA Polymerase II Transcription, organism-specific biosystem; RNA Polymerase II Transcription Termination, organism-specific biosystem; |
Function : | RNA binding; RS domain binding; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
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SRSF1-446H | Recombinant Human SRSF1 Protein, His-tagged | +Inquiry |
SRSF1-2103H | Recombinant Human SRSF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Srsf1-483M | Recombinant Mouse Srsf1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
SRSF1-1910HCL | Recombinant Human SFRS1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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