Native Human ACHE
Cat.No. : | ACHE-8345H |
Product Overview : | Native Human ACHE was purified from Human erythrocytes. |
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- Gene Information
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Description : | Acetylcholinesterase (AChE) is involved in cholinergic transmission, where it catalyses the hydrolysis of the neurotransmitter acetylcholine. A membrane-bound protein on the post-synaptic membrane. Also found in some non-neuronal cells, such as erythrocytes where its function is unclear. The erythrocyte enzyme extracted from the membrane anchor, using Triton-X 100, has a molecular weight 160,000. AChE is the target the organophosphorus insecticides such as parathion and malathion, all of which irreversibly inhibit the enzyme. Depressed levels of AChE activity is a sensitive indicator of exposure to these agents. It is also the target of anti-Alzheimer""s drrugs such as tacrine, which are reversible inhibitors of the enzyme. Raised levels of AChE in amniotic fluid are indicative of foetal neural tube defects. |
Source : | Human erythrocytes |
Species : | Human |
Unit Definition : | One unit will hydrolyse one micromole of Acetylthiocholine Iodide per minute at 37°C and pH 7.4. |
Concentration : | >450 U/mg |
Gene Name : | ACHE acetylcholinesterase [ Homo sapiens ] |
Official Symbol : | ACHE |
Synonyms : | ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE; |
Gene ID : | 43 |
mRNA Refseq : | NM_000665 |
Protein Refseq : | NP_000656 |
MIM : | 100740 |
UniProt ID : | P22303 |
Chromosome Location : | 7q22 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Acetylcholine Synthesis, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Monoamine Transport, organism-specific biosystem; |
Function : | acetylcholine binding; acetylcholine binding; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein homodimerization activity; protein self-association; serine hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
ACHE-106R | Recombinant Rat ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-04H | Active Recombinant Human ACHE Protein, His-tagged | +Inquiry |
Ache-511M | Recombinant Mouse Ache Protein, MYC/DDK-tagged | +Inquiry |
ACHE-2415H | Recombinant Human ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACHE-36R | Recombinant Rhesus Macaque ACHE Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACHE-2163MCL | Recombinant Mouse ACHE cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0034 | Acetylcholinesterase Red Fluorescence Assay Kit | +Inquiry |
Kit-0033 | Acetylcholinesterase Green Fluorescence Assay Kit | +Inquiry |
Kit-0032 | Acetylcholinesterase Assay Kit | +Inquiry |
Kit-0031 | Acetylcholinesterase Activity Colorimetric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionThe time required for different proteins varies, you can pay attention to the information on the product details page, or contact our experts directly.
Sure. We can customize proteins according to customer needs, including different tags, expression system, protein length, etc.
Because we can customize proteins of different lengths according to customer needs, please contact us if you are interested in this product.
Patients with Alzheimer disease often receive treatment with acetylcholinesterase inhibitors that mitigate symptoms by hindering ACh turnover.
Acetylcholinesterase is known to be distributed in nervous tissue such as the brainstem, cerebellum, and peripheral and autonomic nervous systems. Skeletal muscle also contains AChE with distribution patterns seemingly related to the type of muscle (fast versus slow twitch) and their specific function. AChE is also present on red blood cell membranes.
Although the primary function of AChE is to terminate neural transmission, investigators have found that AChE also plays a role in neural development. During fetal development, AChE contributes to morphogenesis in addition to its main enzymatic function.
Acetylcholinesterase exists as a monomer that often polymerizes into a dimer with a disulfide bond. Along with Van der Waals forces, two dimers may be linked to become tetramers.
The primary role of AChE is to terminate neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors. They are an important component of pesticides and nerve agents.
Customer Reviews (2)
Write a reviewI have already recommended creative biomart products to many colleagues.
Received the product very quickly after placing the order, I am very satisfied.
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