|Product Overview:||Native Human ACHE was purified from Human erythrocytes.|
|Description:||Acetylcholinesterase (AChE) is involved in cholinergic transmission, where it catalyses the hydrolysis of the neurotransmitter acetylcholine. A membrane-bound protein on the post-synaptic membrane. Also found in some non-neuronal cells, such as erythrocytes where its function is unclear. The erythrocyte enzyme extracted from the membrane anchor, using Triton-X 100, has a molecular weight 160,000. AChE is the target the organophosphorus insecticides such as parathion and malathion, all of which irreversibly inhibit the enzyme. Depressed levels of AChE activity is a sensitive indicator of exposure to these agents. It is also the target of anti-Alzheimer""s drrugs such as tacrine, which are reversible inhibitors of the enzyme. Raised levels of AChE in amniotic fluid are indicative of foetal neural tube defects.|
|Unit Definition:||One unit will hydrolyse one micromole of Acetylthiocholine Iodide per minute at 37°C and pH 7.4.|
|Gene Name:||ACHE acetylcholinesterase [ Homo sapiens ]|
|Synonyms:||ACHE; acetylcholinesterase; acetylcholinesterase (YT blood group) , acetylcholinesterase (Yt blood group) , YT; Yt blood group; apoptosis-related acetylcholinesterase; YT; ACEE; ARACHE; N-ACHE;|
|Pathway:||ATF-2 transcription factor network, organism-specific biosystem; Acetylcholine Synthesis, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Monoamine Transport, organism-specific biosystem;|
|Function:||acetylcholine binding; acetylcholine binding; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein homodimerization activity; protein self-association; serine hydrolase activity;|
Price does not include shipping and packaging costs.Request quote for final price.