Recombinant Human ARL6IP5 protein, GST-tagged

• Cat.No.: ARL6IP5-9863H
• Product Overview: Recombinant Human ARL6IP5 protein(1-188 aa), fused with GST tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein Length: 1-188 aa
• AA Sequence: MDVNIAPLRAWDDFFPGSDRFARPD FRDISKWNNRVVSNLLYYQTNYLVV AAMMISIVGFLSPFNMILGGIVVVL VFTGFVWAAHNKDVLRRMKKRYPTT FVMVVMLASYFLISMFGGVMVFVFG ITFPLLLMFIHASLRLRNLKNKLEN KMEGIGLKRTPMGIVLDALEQQEEG INRLTDYISKVKE
• Purity: 75%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.
• Publication:
  ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma (2022)

Gene Information

• Gene Name: ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 [ Homo sapiens ]
• Official Symbol: ARL6IP5
• Synonyms: ARL6IP5; ADP-ribosylation-like factor 6 interacting protein 5; PRA1 family protein 3; DERP11; GTRAP3 18; HSPC127; JWA; PRA1 domain family 3; PRAF3; JM5; aip-5; protein JWa; ARL-6-interacting protein 5; dermal papilla derived protein 11; dermal papilla-derived protein 11; prenylated Rab acceptor protein 2; putative MAPK activating protein PM27; putative MAPK-activating protein PM27; glutamate transporter EEAC1-associated protein; glutamate transporter EAAC1-interacting protein; cytoskeleton related vitamin A responsive protein; cytoskeleton-related vitamin A-responsive protein; ADP-ribosylation factor-like protein 6-interacting protein 5; jmx; hp22; addicsin; GTRAP3-18
• Gene ID: 10550
• mRNA Refseq: NM_006407
• Protein Refseq: NP_006398
• MIM: 605709
• UniProt ID: O75915

Reviews

10/20/2022

the ARL6IP5 protein's high quality and its compatibility with my experimental needs, coupled with the manufacturer's excellent technical support, create a valuable alliance that contributes to successful research endeavors.

12/04/2021

The manufacturer's commitment to providing high-quality proteins is evident in their meticulous production process, ensuring the purity and reliability of the ARL6IP5 protein.

03/20/2020

ARL6IP5 protein is highly recommended for researchers due to its excellent performance in WB experiments and its utility in protein electron microscopy structure analysis.

01/02/2020

Its reliability and versatility make it an essential tool for investigating ARL6IP5 protein's expression, function, and structural characteristics.

08/25/2019

This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

06/25/2019

By visualizing the structural features, interactions, and conformational changes of ARL6IP5, researchers gain valuable insights into its function and potential for therapeutic interventions.

10/04/2018

The ARL6IP5 protein is characterized by its exceptional quality, making it an ideal choice to fulfill my experimental requirements.

05/06/2017

The use of ARL6IP5 protein in such analyses provides valuable structural insights that contribute to the elucidation of ANO2's functional mechanisms and potential drug targeting sites.

Q&As

Has ARL6IP5 been implicated in any diseases?

ARL6IP5 mutations have been associated with Bardet-Biedl syndrome (BBS), a rare genetic disorder characterized by vision impairment, obesity, kidney dysfunction, and other symptoms. These findings suggest a role for ARL6IP5 in ciliopathies.

What are the research implications of studying ARL6IP5?

Investigating ARL6IP5 can enhance our understanding of the molecular mechanisms underlying Bardet-Biedl syndrome and other ciliopathies. It may also provide insights into intracellular trafficking pathways and potential therapeutic targets for related disorders.

Are there any known post-translational modifications of ARL6IP5?

Limited information is available on post-translational modifications of ARL6IP5. However, it is speculated that phosphorylation events may modulate its function and protein-protein interactions.

How does ARL6IP5 contribute to cell function?

ARL6IP5 is involved in vesicular traffic between the Golgi apparatus and the plasma membrane. It interacts with other proteins, such as the small GTPase Arl6, to regulate processes like protein trafficking and secretion.