Active Recombinant Human METAP2, His-tagged
Cat.No. : | METAP2-635H |
Product Overview : | Recombinant Human METAP2 (Ala2-Tyr478) fused with 10His tag at Cterminal, was expressed in Spodoptera frugiperda. |
- Specification
- Gene Information
- Related Products
Cat. No. : | METAP2-635H |
Description : | This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. |
Source : | Spodoptera frugiperda |
Molecular Mass : | 54 kDa |
N-terminal SequenceAnalysis : | Ala2 |
Formulation : | Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Activity : | Measure by its ability to remove methionine from a fluorogenic peptide substrate H-Met-Gly-Pro-AMC. The resulting GP-AMC is cleaved by Recombinant Human DPPIV/CD26. The specific activity is >15 pmol/min/µg, as measured using the described conditions. |
EndotoxinLevel : | <1.0 EU per 1 μg of the protein by the LAL method. |
Storage : | 6 months from date of receipt, 70 °C as supplied. Avoid repeated freezethaw cycles. |
OfficialSymbol : | METAP2 |
Gene Name : | METAP2 methionyl aminopeptidase 2 [ Homo sapiens ] |
Synonyms : | METAP2; methionyl aminopeptidase 2; MAP 2; Peptidase M; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; metAP 2; methionine aminopeptidase 2; peptidase M 2; p67; MAP2; MNPEP; p67eIF2; EC 3.4.11.18 |
Gene ID : | 10988 |
mRNA Refseq : | NM_006838 |
Protein Refseq : | NP_006829 |
MIM : | 601870 |
UniProt ID : | P50579 |
Chromosome Location : | 12q22 |
Function : | aminopeptidase activity; metal ion binding; metalloexopeptidase activity |
Products Types
◆ Recombinant Protein | ||
METAP2-876M | Active Recombinant Mouse METAP2 protein(Ala2-Tyr478), His-tagged | +Inquiry |
METAP2-1109H | Recombinant Human METAP2 Protein, His&SUMO-tagged | +Inquiry |
METAP2-1454H | Recombinant Human METAP2 Protein (2-478 aa), His-tagged | +Inquiry |
METAP2-4415H | Recombinant Human METAP2 Protein, GST-tagged | +Inquiry |
METAP2-2557R | Recombinant Rhesus Macaque METAP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
METAP2-457MCL | Recombinant Mouse METAP2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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