Active Recombinant Human PNP, His-tagged
Cat.No. : | PNP-150H |
Product Overview : | Recombinant Human PNP (Met1-Ser289) fused with 6His tag at Cterminal, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met1 |
Form : | Supplied as a 0.2 µm filtered solution in Tris and NaCl. |
Bio-activity : | Measured by the phosphorolysis of 7-methyl-6-thioguanosine. The specific activity is >35,000 pmol/min/µg, as measured under the described conditions. |
Molecular Mass : | 33 kDa |
Endotoxin : | < 1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening. |
Shipping : | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
Gene Name : | PNP purine nucleoside phosphorylase [ Homo sapiens (human) ] |
Official Symbol : | PNP |
Synonyms : | PNP; NP; PUNP; PRO1837; purine nucleoside phosphorylase; inosine phosphorylase; inosine-guanosine phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1 |
Gene ID : | 4860 |
mRNA Refseq : | NM_000270 |
Protein Refseq : | NP_000261 |
MIM : | 164050 |
UniProt ID : | P00491 |
Chromosome Location : | 14q13.1 |
Pathway : | Metabolism; Metabolism of nucleotides; Nicotinate and nicotinamide metabolism |
Function : | drug binding; nucleoside binding; phosphate ion binding |
Products Types
◆ Recombinant Protein | ||
PNP-6887M | Recombinant Mouse PNP Protein, His (Fc)-Avi-tagged | +Inquiry |
Pnp-4971M | Recombinant Mouse Pnp Protein, Myc/DDK-tagged | +Inquiry |
PNP-2498H | Recombinant Human PNP protein(11-280 aa), C-His-tagged | +Inquiry |
PNP-3312R | Recombinant Rhesus Macaque PNP Protein, His (Fc)-Avi-tagged | +Inquiry |
PNP-1723H | Recombinant Human PNP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PNP-3071HCL | Recombinant Human PNP 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-0712 | Purine Nucleoside Phosphorylase Activity Fluorometric Assay Kit | +Inquiry |
Kit-0711 | Purine Nucleoside Phosphorylase Activity Colorimetric Assay Kit | +Inquiry |
Kit-0877 | PNP Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket