Active Recombinant Human ROR1, GST-tagged
Cat.No. : | ROR1-232H |
Product Overview : | Recombinant human ROR1(429-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Description : | ROR1 is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors that play a role in the control of most basic cellular processes including cell proliferation, differentiation, migration and metabolism. Many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma is associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | The specific activity of ROR1 was determined to be 0.2 nmol /min/mg |
Molecular Mass : | ~82 kDa |
Purity : | >95% by densitometry |
Applications : | Kinase Assay, Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | ROR1 receptor tyrosine kinase-like orphan receptor 1 [ Homo sapiens ] |
Official Symbol : | ROR1 |
Synonyms : | ROR1; receptor tyrosine kinase-like orphan receptor 1; NTRKR1; tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase receptor-related 1; neurotrophic tyrosine kinase, receptor-related 1; dJ537F10.1; MGC99659; |
Gene ID : | 4919 |
mRNA Refseq : | NM_001083592 |
Protein Refseq : | NP_001077061 |
MIM : | 602336 |
UniProt ID : | Q01973 |
Chromosome Location : | 1p32-p31 |
Pathway : | Nuclear Receptors, organism-specific biosystem; |
Function : | ATP binding; Wnt-protein binding; kinase activity; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
ROR1-428H | Recombinant Human ROR1 Protein, His-tagged | +Inquiry |
Ror1-513M | Recombinant Mouse Ror1 Protein, His-tagged | +Inquiry |
ROR1-1905H | Recombinant Human ROR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ROR1-1064H | Recombinant Human ROR1 protein(Met1-Glu403), His-tagged | +Inquiry |
ROR1-595H | Recombinant Human ROR1 Protein (Met1-Glu403), Biotinylated | +Inquiry |
◆ Lysates | ||
ROR1-002HCL | Recombinant Human ROR1 cell lysate | +Inquiry |
ROR1-001HCL | Recombinant Human ROR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (4)
Ask a questionROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.
Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.
ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.
ROR1 is involved in the study of breast, lung and ovarian cancers.
Customer Reviews (3)
Write a reviewCustomer service promptly feedback my requests, technical staff timely solve the problems that arise.
Excellent after-sales service, solving many experimental problems.
Fast and timely shipment helped me to get satisfactory experimental results in short time.
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