Recombinant Human PDCD1, His-tagged, Biotinylated
Cat.No. : | PDCD1-257H |
Product Overview : | Human PD-1 /PDCD1 Protein, Biotinylated (Biotinylated PD-1 / PDCD1) Pro 21 - 167 Gln, was labeled with biotin based on rhPD1 Protein, which was produced in human 293 cells (HEK293). |
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Description : | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization. |
Molecular Mass : | Biotinylated PD-1 / PDCD1, fused with 6×His tag at the C-terminus, has a calculated MW of 17.3 kDa. The predicted N-terminus is Pro 21. DTT-reduced Protein migrates as 38-42 kDa due to glycosylation. |
Endotoxin : | Less than 1.0 EU per μg of the Biotinylated PD-1 / PDCD1 by the LAL method. |
Purity : | >95% as determined by reduced SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). |
Gene Name : | PDCD1 programmed cell death 1 [ Homo sapiens ] |
Official Symbol : | PDCD1 |
Synonyms : | PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l; |
Gene ID : | 5133 |
mRNA Refseq : | NM_005018 |
Protein Refseq : | NP_005009 |
MIM : | 600244 |
UniProt ID : | Q15116 |
Chromosome Location : | 2q37.3 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem; |
Function : | protein binding; protein tyrosine phosphatase activity; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
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Pdcd1-160M | Active Recombinant Mouse Pdcd1 protein(Met1-Gln167), hFc-tagged | +Inquiry |
PDCD1-703R | Recombinant Rat PDCD1 Protein | +Inquiry |
PDCD1-692C | Recombinant Cynomolgus monkey PDCD1 Protein | +Inquiry |
◆ Lysates | ||
PDCD1-2628MCL | Recombinant Mouse PDCD1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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