Recombinant Human PSEN1, His-tagged

• Cat.No.: PSEN1-2004H
• Product Overview: Recombinant Human PSEN1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 254-377aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: PSEN1 presenilin 1 [ Homo sapiens ]
• Official Symbol: PSEN1
• Synonyms: PSEN1; presenilin 1; AD3, Alzheimer disease 3; presenilin-1; FAD; PS1; S182; AD3; PS-1
• Gene ID: 5663
• mRNA Refseq: NM_000021
• Protein Refseq: NP_000012
• MIM: 104311
• UniProt ID: P49768
• Chromosome Location: 14q24.3
• Pathway: Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; NRIF signals cell death from the nucleus, organism-specific biosystem; Neurotrophin signaling pathway, organism-specific biosystem
• Function: PDZ domain binding; aspartic-type endopeptidase activity; beta-catenin binding; cadherin binding; calcium channel activity; endopeptidase activity; endopeptidase activity; peptidase activity; protein binding