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Recombinant Human TAF1, GST-tagged

Cat.No. : TAF1-122H
Product Overview : Recombinant Human TAF1, amino-acids 1400 – 1651, fused with GST-tag at N-terminal, was expressed in an E. coli expression system.
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Description : Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons.
Source : E. coli
Species : Human
Tag : GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Molecular Mass : 56.1 kDa
Purity : ≥95% by SDS-PAGE
Applications : Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Stability : >6 months at –80°C
Gene Name : TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa [ Homo sapiens (human) ]
Official Symbol : TAF1
Synonyms : TAF1; OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S; NP_004597.2; EC 2.7.11.1; NP_620278.1
Gene ID : 6872
mRNA Refseq : NM_004606
Protein Refseq : NP_004597
MIM : 313650
UniProt ID : P21675
Chromosome Location : Xq13.1
Pathway : Basal transcription factors; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Transcription
Function : TBP-class protein binding; histone acetyl-lysine binding; protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which TAF1 modulates the expression of specific sets of genes? 11/17/2022

TAF1 specifically modulates the expression of certain genes, impacting diverse cellular functions and processes.

How does TAF1 (TATA-Box Binding Protein Associated Factor 1) regulate transcription initiation by RNA polymerase II? 05/03/2022

TAF1 is pivotal in initiating transcription by RNA polymerase II, regulating the early steps of gene expression.

How does TAF1 contribute to the regulation of gene expression in response to cellular signals and stress? 09/30/2021

TAF1 responds to cellular signals and stress, adapting gene expression to meet cellular needs and challenges.

How does TAF1 influence chromatin remodeling and accessibility of DNA for transcription? 04/21/2021

TAF1 plays a role in chromatin remodeling, making DNA accessible for transcription and regulating gene activity.

How do alterations in TAF1 expression or function affect the cell cycle and apoptosis? 03/11/2019

Changes in TAF1 can influence key cellular processes like the cell cycle and programmed cell death.

What role does TAF1 play in the assembly and function of the transcription factor IID (TFIID) complex? 08/05/2018

TAF1 is integral to the TFIID complex, essential for accurate and efficient transcription initiation.

What is the impact of TAF1 mutations on neurodevelopmental disorders and intellectual disabilities? 02/06/2018

Mutations in TAF1 are linked to neurodevelopmental disorders, affecting brain development and function.

Customer Reviews (3)

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Reviews
10/20/2021

    Expertise in peptide synthesis, accelerates our peptide-based research.

    04/15/2019

      Swift protein quantification, improves data reliability in our work.

      11/26/2018

        Reliable protein crystallography, key for our structural biology research.

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